Alix and ALG-2 make a link between endosomes and neuronal death
| Autor: | Béatrice Blot, Jean Marc Verna, Christine Chatellard-Causse, David Béal, Sandrine Fraboulet, Anne Petiot, Sakina Torch, Anne-Laure Mahul-Mellier, Flavie Strappazzon, Rémy Sadoul, Fiona J. Hemming |
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| Přispěvatelé: | Grenoble Institut des Neurosciences (GIN), Université Joseph Fourier - Grenoble 1 (UJF)-Institut National de la Santé et de la Recherche Médicale (INSERM), This work was supported in part by Inserm, the University Joseph Fourier, grants from the Association Franc¸ aise contre les Myopathies [grant number MNM 2007], the Association pour la Recherche sur la Scle' rose Late' rale Amyotrophique [grant number 060711] and the Association pour la Recherche contre le Cancer [grant number 4948]. A.-L.M.-M. was supported by a fellowship from the Association Franc¸ aise contre les Myopathies., Fraboulet, Sandrine |
| Rok vydání: | 2009 |
| Předmět: |
MESH: Cell Death
MESH: Enzyme Activation Programmed cell death Endosome caspase MESH: Neurons Endosomes MESH: Calcium-Binding Proteins Biochemistry ESCRT 03 medical and health sciences Enzyme activator 0302 clinical medicine [SDV.BBM] Life Sciences [q-bio]/Biochemistry Molecular Biology Animals Humans MESH: Animals [SDV.BBM]Life Sciences [q-bio]/Biochemistry Molecular Biology Receptor endosomal sorting complex required for transport (ESCRT) Caspase 030304 developmental biology Neurons 0303 health sciences calcium MESH: Caspases MESH: Humans Cell Death biology tumour necrosis factor α receptor 1 (TNFR1) Calcium-Binding Proteins apoptosis Signal transducing adaptor protein neuron Cell biology Enzyme Activation MESH: Endosomes Apoptosis Caspases biology.protein 030217 neurology & neurosurgery |
| Zdroj: | Biochemical Society Transactions Biochemical Society Transactions, Portland Press, 2009, 37 (Pt 1), pp.200-3. ⟨10.1042/BST0370200⟩ |
| ISSN: | 1470-8752 0300-5127 |
| DOI: | 10.1042/bst0370200 |
| Popis: | International audience; Alix [ALG-2 (apoptosis-linked gene 2)-interacting protein X] is a ubiquitinous adaptor protein first described for its capacity to bind to the calcium-binding protein, ALG-2. Alix regulates neuronal death in ways involving interactions with ALG-2 and with proteins of the ESCRT (endosomal sorting complex required for transport). Even though all Alix interactors characterized to date are involved in endosomal trafficking, the genuine function of the protein in this process remains unclear. We have demonstrated recently that Alix and ALG-2 form in the presence of calcium, a complex with apical caspases and with the endocytosed death receptor TNFR1 (tumour necrosis factor alpha receptor 1), thus suggesting a molecular coupling between endosomes and the cell death machinery. |
| Databáze: | OpenAIRE |
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