Association of vascular risk factors with cervical artery dissection and ischemic stroke in young adults

Autor: Debette, Stéphanie, Metso, Tiina, Pezzini, Alessandro, Abboud, Shérine, Metso, Antti, Leys, Didier, Bersano, Anna, Louillet, Fabien, Caso, Valeria, Lamy, Chantal, Medeiros, Elisabeth, Samson, Yves, Grond-Ginsbach, Caspar, Engelter, Stefan T, Thijs, Vincent, Beretta, Simone, Béjot, Yannick, Sessa, Maria, Lorenza Muiesan, Maria, Amouyel, Philippe, Castellano, Maurizio, Arveiler, Dominique, Tatlisumak, Turgut, Dallongeville, Jean, Renseigné, Non
Přispěvatelé: Troubles cognitifs vasculaires et dégénératifs, Université de Lille, Sciences et Technologies, Equipe NEMESIS - Centre de Recherches de l'Institut du Cerveau et de la Moelle épinière (NEMESIS-CRICM), Centre de Recherche de l'Institut du Cerveau et de la Moelle épinière (CRICM), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre d'épidémiologie des populations (CEP), Université de Bourgogne (UB)-Centre Régional de Lutte contre le cancer Georges-François Leclerc [Dijon] (UNICANCER/CRLCC-CGFL), UNICANCER-UNICANCER, Epidémiologie des maladies chroniques : impact des interactions gène environnement sur la santé des populations, Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille, Droit et Santé, Dept. Atherosclerose, Debette, S, Metso, T, Pezzini, A, Abboud, S, Metso, A, Leys, D, Bersano, A, Louillet, F, Caso, V, Lamy, C, Medeiros, E, Samson, Y, Grond Ginsbach, C, Engelter, S, Thijs, V, Beretta, S, Béjot, Y, Sessa, M, Lorenza Muiesan, M, Amouyel, P, Castellano, M, Arveiler, D, Tatlisumak, T, Dallongeville, J, Ferrarese, C, Equipe NEMESIS - Centre de Recherches de l'Institut du Cerveau et de la Moelle épinière ( NEMESIS-CRICM ), Centre de Recherche de l'Institut du Cerveau et de la Moelle épinière ( CRICM ), Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre National de la Recherche Scientifique ( CNRS ) -Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre National de la Recherche Scientifique ( CNRS ), Centre d'épidémiologie des populations ( CEP ), Université de Bourgogne ( UB ) -Centre Régional de Lutte contre le cancer - Centre Georges-François Leclerc ( CRLCC - CGFL ), Réseau International des Instituts Pasteur ( RIIP ) -Réseau International des Instituts Pasteur ( RIIP ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Université de Lille, Droit et Santé
Jazyk: angličtina
Rok vydání: 2011
Předmět:
Adult
Male
medicine.medical_specialty
obesity
hypertension
Cervical Artery
Anterior Spinal Artery Syndrome
Comorbidity
030204 cardiovascular system & hematology
Diabetes Complications
03 medical and health sciences
0302 clinical medicine
Risk Factors
Retrospective Studie
Physiology (medical)
Diabetes mellitus
Internal medicine
Diabetes Complication
Prevalence
[INFO.INFO-IM]Computer Science [cs]/Medical Imaging
Medicine
Humans
Risk factor
10. No inequality
Stroke
Retrospective Studies
2. Zero hunger
[ INFO.INFO-IM ] Computer Science [cs]/Medical Imaging
hypercholesterolemia
business.industry
Vascular disease
Cerebral infarction
Risk Factor
Smoking
Middle Aged
medicine.disease
stroke
3. Good health
Surgery
dissection
Female
Cardiology and Cardiovascular Medicine
business
Body mass index
030217 neurology & neurosurgery
Human
Zdroj: Circulation
Circulation, 2011, 123 (14), pp.1537-1544. ⟨10.1161/CIRCULATIONAHA.110.000125⟩
Circulation, American Heart Association, 2011, 123 (14), pp.1537-1544. 〈10.1161/CIRCULATIONAHA.110.000125〉
Circulation, American Heart Association, 2011, 123 (14), pp.1537-1544. ⟨10.1161/CIRCULATIONAHA.110.000125⟩
ISSN: 0009-7322
1524-4539
Popis: Background— Little is known about the risk factors for cervical artery dissection (CEAD), a major cause of ischemic stroke (IS) in young adults. Hypertension, diabetes mellitus, smoking, hypercholesterolemia, and obesity are important risk factors for IS. However, their specific role in CEAD is poorly investigated. Our aim was to compare the prevalence of vascular risk factors in CEAD patients versus referents and patients who suffered an IS of a cause other than CEAD (non-CEAD IS) in the multicenter Cervical Artery Dissection and Ischemic Stroke Patients (CADISP) study. Methods and Results— The study sample comprised 690 CEAD patients (mean age, 44.2±9.9 years; 43.9% women), 556 patients with a non-CEAD IS (44.7±10.5 years; 39.9% women), and 1170 referents (45.9±8.1 years; 44.1% women). We compared the prevalence of hypertension, diabetes mellitus, hypercholesterolemia, smoking, and obesity (body mass index ≥30 kg/m 2 ) or overweightness (body mass index ≥25 kg/m 2 and 2 ) between the 3 groups using a multinomial logistic regression adjusted for country of inclusion, age, and gender. Compared with referents, CEAD patients had a lower prevalence of hypercholesterolemia (odds ratio 0.55; 95% confidence interval, 0.42 to 0.71; P P P =0.002) but were more frequently hypertensive (odds ratio 1.67; 95% confidence interval, 1.32 to 2.1; P Conclusion— These results, from the largest series to date, suggest that hypertension, although less prevalent than in patients with a non-CEAD IS, could be a risk factor of CEAD, whereas hypercholesterolemia, obesity, and overweightness are inversely associated with CEAD.
Databáze: OpenAIRE
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