Comparative analysis between urinary calprotectin and serum creatinine for early detection of intrinsic acute kidney injury
Autor: | Marjan Vakili, Mastaneh Moghtaderi, Seyed-Taher Esfahani, Meysam Sharifzadeh, Daryoush Fahimi |
---|---|
Jazyk: | angličtina |
Rok vydání: | 2021 |
Předmět: |
medicine.medical_specialty
Urinary system Urine urologic and male genital diseases calprotectin Gastroenterology serum creatinine chemistry.chemical_compound fluids and secretions Internal medicine Intensive care medicine Creatinine business.industry Acute kidney injury medicine.disease intrinsic aki Diseases of the genitourinary system. Urology chemistry acute kidney injury Nephrology Biomarker (medicine) Original Article RC870-923 Calprotectin business Kidney disease |
Zdroj: | Indian Journal of Nephrology, Vol 31, Iss 4, Pp 353-357 (2021) Indian Journal of Nephrology |
ISSN: | 1998-3662 0971-4065 |
Popis: | Background: Acute kidney injury (AKI) is a common and important clinical condition that may lead to chronic kidney disease if it is not diagnosed and treated in its early stages. Urinary calprotectin is a valuable recognized biomarker that can be used to differentiate prerenal and intrinsic AKI. However, till date only a few reports on urine calprotectin measurement in early diagnosis of intrinsic AKI are available. In this study, we compared the sensitivity and specificity of urinary calprotectin with those of serum creatinine in detecting early intrinsic AKI. Methods: Over 6 months period (April to October 2018), 81 of 408 patients admitted to the pediatric intensive care unit met the criteria of this cross-sectional study. Their serum creatinine and urinary calprotectin were measured on the first and third day of admission using Jaffe and Elisa radioimmunoassay methods, respectively. The AKI was defined according to the pRIFLE criteria. Results: Of the total 81 patients, 67 had the criteria of intrinsic AKI. Of these 62% were female and 38% were male. The mean age of the patients was 22 months. According to data analysis, the area under the curve of ROC of urinary calprotectin on day-1 to detect renal failure is 0.93 with the best cutoff point obtained at 530 ng/mL. The sensitivity, specificity, positive, and negative predictive values of urinary calprotectin levels in diagnosing AKI at this cutoff point are 92.5%, 92.8%, 98.4, and 72.2%, respectively. Besides, urinary calprotectin changes occur much earlier than the rising of serum creatinine. Conclusion: Urinary level of calprotectin is a very sensitive biomarker for early diagnosis of intrinsic AKI in children and it can be used in intensive care units or anywhere critically ill children admitted to detect intrinsic AKI. Besides, this study shows that urine calprotectin may be a more sensitive and specific biomarker than serum creatinine in the early phases of intrinsic AKI. |
Databáze: | OpenAIRE |
Externí odkaz: |