Total liquid ventilation provides superior respiratory support to conventional mechanical ventilation in a large animal model of severe respiratory failure
| Autor: | Kathryn R. Osterholzer, Anne C. Kim, David O. Brant, Kent J. Johnson, Keith E. Cook, Morgan A. Daul, Joshua R. Pohlmann, Ronald B. Hirschl, Junewai L. Reoma, Robert H. Bartlett |
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| Rok vydání: | 2011 |
| Předmět: |
ARDS
Liquid Ventilation medicine.medical_treatment Biomedical Engineering Biophysics Hemodynamics Bioengineering FOS: Medical engineering pCO2 Article Biomaterials Respiration medicine Animals Humans Lung Mechanical ventilation Respiratory Distress Syndrome Sheep business.industry Pulmonary Gas Exchange 90399 Biomedical Engineering not elsewhere classified General Medicine medicine.disease Respiration Artificial Pathophysiology Disease Models Animal medicine.anatomical_structure Respiratory failure Anesthesia business Respiratory Insufficiency |
| DOI: | 10.1184/r1/6096950.v1 |
| Popis: | Total liquid ventilation (TLV) has the potential to provide respiratory support superior to conventional mechanical ventilation (CMV) in the acute respiratory distress syndrome (ARDS). However, laboratory studies are limited to trials in small animals for no longer than 4 hours. The objective of this study was to compare TLV and CMV in a large animal model of ARDS for 24 hours. Ten sheep weighing 53 ± 4 (SD) kg were anesthetized and ventilated with 100% oxygen. Oleic acid was injected into the pulmonary circulation until PaO2:FiO2 ≤ 60 mm Hg, followed by transition to a protective CMV protocol (n = 5) or TLV (n = 5) for 24 hours. Pathophysiology was recorded, and the lungs were harvested for histological analysis. Animals treated with CMV became progressively hypoxic and hypercarbic despite maximum ventilatory support. Sheep treated with TLV maintained normal blood gases with statistically greater PO2 (p < 10(-9)) and lower PCO2 (p < 10(-3)) than the CMV group. Survival at 24 hours in the TLV and CMV groups were 100% and 40%, respectively (p < 0.05). Thus, TLV provided gas exchange superior to CMV in this laboratory model of severe ARDS. |
| Databáze: | OpenAIRE |
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