Effect of Glucose Improvement on Nocturnal Sleep Breathing Parameters in Patients with Type 2 Diabetes : The Candy Dreams Study
| Autor: | Anna Michaela Gaeta, Carolina López-Cano, Marta Hernández, Ferran Barbé, Mireia Dalmases, Liliana Gutiérrez-Carrasquilla, Angela Campos, Albert Lecube, Enric Sánchez, Cristina Hernández, Rafael Simó, Paola Carmona |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Apnea Population lcsh:Medicine 030209 endocrinology & metabolism Type 2 diabetes Article 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Glycated hemoglobin Weight loss Internal medicine medicine education Hypoxia Glycemic education.field_of_study diabetes hypoxia business.industry lcsh:R Diabetes General Medicine apnea medicine.disease Obstructive sleep apnea chemistry Cardiology medicine.symptom business Body mass index 030217 neurology & neurosurgery glycated hemoglobin |
| Zdroj: | Recercat: Dipósit de la Recerca de Catalunya Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) Recercat. Dipósit de la Recerca de Catalunya instname Repositorio Abierto de la UdL Universitad de Lleida Journal of Clinical Medicine, Vol 9, Iss 1022, p 1022 (2020) Journal of Clinical Medicine Volume 9 Issue 4 Dipòsit Digital de Documents de la UAB Universitat Autònoma de Barcelona |
| Popis: | Type 2 diabetes exerts a negative impact on sleep breathing. It is unknown whether a long-term improvement in glycemic control ameliorates this effect. We conducted an interventional study with 35 patients with type 2 diabetes and obstructive sleep apnea (OSA) to explore this. At home, sleep breathing parameters were assessed at baseline and after a 4-month period in which antidiabetic therapy was intensified. Patients who decreased their body mass index &ge 2kg/m2 were excluded. Those with an HbA1c reduction &ge 0.5% were considered good responders (n = 24). After the follow-up, good responders exhibited an improvement in the apnea&ndash hypopnea index (AHI: 26-1 (95% IC: 8.6&ndash 95.0) vs. 20.0 (4.0&ndash 62.4) events/hour, p = 0.002) and in time with oxygen saturation below 90% (CT90: 13.3 (0.4&ndash 69.0) vs. 8.1 (0.4&ndash 71.2) %, p = 0.002). No changes were observed in the group of non&ndash responders (p = 0.722 and p = 0.138, respectively). The percentage of moderate and severe OSA decreased among good responders (p = 0.040). In the wider population, the change in HbA1c correlated positively to decreases in AHI (r = 0.358, p = 0.035) and negatively to increases in the minimum arterial oxygen saturation (r = &minus 0.386, p = 0.039). Stepwise multivariate regression analysis showed that baseline AHI and the absolute change in HbA1c independently predicted decreased AHI (R2 = 0.496). The improvement of glycemic control exerts beneficial effects on sleep breathing parameters in type 2 diabetes, which cannot be attributed merely to weight loss. |
| Databáze: | OpenAIRE |
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