A Community Study of the Relation of Alpha1-Antitrypsin Levels to Obstructive Lung Diseases
| Autor: | Ronald J. Knudson, Benjamin Burrows, Michael D. Lebowitz, James O. Morse |
|---|---|
| Rok vydání: | 1975 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Vital Capacity Population Intermediate level Sex Factors Pregnancy Surveys and Questionnaires alpha 1-Antitrypsin Deficiency Internal medicine Humans Medicine Lung Diseases Obstructive Respiratory system Risk factor Child education Analysis of Variance education.field_of_study Lung business.industry Smoking Age Factors Arizona Estrogens Ventilatory function General Medicine Middle Aged Quantitative determination respiratory tract diseases medicine.anatomical_structure Spirometry Lung disease Child Preschool alpha 1-Antitrypsin Immunology Regression Analysis Female Epidemiologic Methods business |
| Zdroj: | New England Journal of Medicine. 292:278-281 |
| ISSN: | 1533-4406 0028-4793 |
| Popis: | Since it is still uncertain whether moderate degrees of alpha1-antitrypsin deficiency predispose to the development of lung disease, data obtained from a stratified random sample of white households in Tucson, Arizona, consisting of 2586 subjects over five years of age, were analyzed. No relation was found between serum alpha1-antitrypsin levels, measured as trypsin inhibitory capacity, and ventilatory function, respiratory symptomatology, or frequency of diagnosed pulmonary diseases even among cigarette smokers. The data indicate that an intermediate level of alpha1-antitrypsin deficiency (i.e., inhibitory capacity between 20 and 62 per cent of the population's mean value) is not an important risk factor for the development of chronic obstructive lung diseases. The data militate strongly against the use of any quantitative determination of alpha1-antitrypsin as a test to identify subjects with moderate deficiency for the purpose of predicting later development of chronic respiratory disorders. The rate of severe deficiency is so low as to make population screening for such subjects impractical. |
| Databáze: | OpenAIRE |
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