Evaluation of Soluble Fas Ligand as a Serological Marker for Melanoma
| Autor: | Giulia Melzani, Giovanni Parrinello, Giovanni Mori, Giuseppe De Panfilis, Ausilia Maria Manganoni, Giovanna Bugari |
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| Rok vydání: | 2002 |
| Předmět: |
Adult
Male Fas Ligand Protein Skin Neoplasms Adolescent Cell Enzyme-Linked Immunosorbent Assay Dermatology Biology Fas ligand Serology Antigens Neoplasm Biomarkers Tumor medicine Humans fas Receptor Child Melanoma Aged Aged 80 and over Membrane Glycoproteins fungi food and beverages Middle Aged medicine.disease Soluble fas ligand Membrane glycoproteins medicine.anatomical_structure Membrane Apoptosis Cancer research biology.protein Female |
| Zdroj: | Dermatology. 205:111-115 |
| ISSN: | 1421-9832 1018-8665 |
| DOI: | 10.1159/000063894 |
| Popis: | Background: Fas ligand (Fas-L), which is expressed by melanoma cells, can be cleaved from cell membranes and become soluble (soluble Fas-L, sFas-L). No previous study examined sFas-L levels in patients affected with all clinical stages of melanoma. Objective: To investigate if sFas-L can be considered a serological marker for melanoma. Methods: Serological sFas-L values in 114 patients with melanoma and 25 controls were measured by using ELISA. Results: sFas-L values in patients were not significantly higher than in controls. They were not significantly different, moreover, when patient groups belonging to different clinical stages were compared with the control group. Two patients affected with distant metastases had the highest sFas-L values. Conclusion: sFas-L cannot be considered, within the limits of this study, as a serological marker for the detection of melanoma. Further studies are needed to evaluate whether sFas-L can be used as a marker for disease progression and/or prediction of therapy outcome. |
| Databáze: | OpenAIRE |
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