The Elevation in Preoperative Procalcitonin Is Associated with a Poor Prognosis for Patients Undergoing Resection for Colorectal Cancer
| Autor: | Tomoyuki Ueki, Masatsugu Kojima, Yoshihiro Endo, Hiroyuki Ohta, Toru Miyake, Tsuyoshi Yamaguchi, Masaji Tani, Eiji Mekata, Tomoharu Shimizu, Sachiko Kaida, Hiroya Iida |
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| Rok vydání: | 2020 |
| Předmět: |
Male
congenital hereditary and neonatal diseases and abnormalities medicine.medical_specialty Poor prognosis mGPS Multivariate analysis Colorectal cancer Gastroenterology Procalcitonin Sepsis Internal medicine parasitic diseases Biomarkers Tumor medicine Humans Clinical significance Stage (cooking) Risk factor Retrospective Studies business.industry Prognostic nutritional index Middle Aged Prognosis bacterial infections and mycoses medicine.disease Preoperative Period Female Surgery Colorectal Neoplasms Infection business hormones hormone substitutes and hormone antagonists |
| Zdroj: | Digestive Surgery. 38:80-86 |
| ISSN: | 1421-9883 0253-4886 |
| Popis: | Background:Procalcitonin (PCT) is a well-known marker for bacterial infection; however, the clinical significance of PCT in the long-term prognosis after colorectal cancer (CRC) surgery remains unclear. Methods:This is a retrospective review of 277 patients that underwent CRC surgery to investigate the relationship between preoperative PCT, clinicopathological condition, cancer-specific overall survival (OS), and relapse-free survival (RFS). Results:Median follow-up interval was 5.0 years in all patients. Thirty-six patients developed recurrence, and 46 patients died due to recurrences or metastases of CRC. Preoperative PCT levels were highest in Stage IV patients. The cancer-specific OS in patients with Stage IV/PCT ≤0.05 ng/mL was significantly higher than those with Stage IV/PCT >0.05 ng/mL (3 years survival; 42.3 vs. 14.3%, p = 0.0413). On multivariate analysis, gender, TNM classification, and PCT were identified as significant risk factors for cancer-specific OS in patients with Stage I-III CRC. The cancer-specific OS rate of these patients with PCT ≥0.08 ng/mL, compared with PCT Conclusion:High preoperative PCT values in CRC patients appeared to be associated with poor OS but not RFS following surgical treatments. |
| Databáze: | OpenAIRE |
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