Leucosceptroid B from glandular trichomes of Leucosceptrum canum reduces fat accumulation in Caenorhabditis elegans through suppressing unsaturated fatty acid biosynthesis
| Autor: | Yan Liu, Yi Ling, De-Sen Li, Shi-Hong Luo, Yan-Chun Liu, Juan Hua, Lin-Lin Teng, Sheng-Hong Li |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
food.ingredient
Sesterterpenes Mutant Leucosceptrum canum 01 natural sciences 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine food Biosynthesis Drug Discovery Animals Caenorhabditis elegans Gene Unsaturated fatty acid chemistry.chemical_classification Lamiaceae biology 010405 organic chemistry Fatty acid Lipid metabolism General Medicine Trichomes biology.organism_classification 0104 chemical sciences Complementary and alternative medicine chemistry Biochemistry 030220 oncology & carcinogenesis Fatty Acids Unsaturated |
| Zdroj: | Chinese journal of natural medicines. 17(12) |
| ISSN: | 1875-5364 |
| Popis: | Obesity that is highly associated with numerous metabolic diseases has become a global health issue nowdays. Plant sesterterpenoids are an important group of natural products with great potential; thus, their bioactivities deserve extensive exploration. RNA-seq analysis indicated that leucosceptroid B, a sesterterpenoid previously discovered from the glandular trichomes of Leucosceptrum canum, significantly regulated the expression of 10 genes involved in lipid metabolism in Caenorhabditis elegans. Furthermore, leucosceptroid B was found to reduce fat storage, and downregulate the expression of two stearoyl-CoA desaturase (SCD) genes fat-6 and fat-7, and a fatty acid elongase gene elo-2 in wild-type C. elegans. In addition, leucosceptroid B significantly decreased fat accumulation in both fat-6 and fat-7 mutant worms but did not affect the fat storage of fat-6; fat-7 double mutant. These findings indicated that leucosceptroid B reduced fat storage depending on the downregulated expression of fat-6, fat-7 and elo-2 and thereby inhibiting the biosynthesis of the corresponding unsaturated fatty acid. These findings provide new insights into the development and utilization of plant sesterterpenoids as potential antilipemic agents. |
| Databáze: | OpenAIRE |
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