Cyanation of glycine derivatives
| Autor: | Jia Liang, Tongzhi Sang, Yong Yuan, Congde Huo, Xiazhen Bao, Lanlan Ou, Ying Fu |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Reaction conditions
Metals and Alloys Substrate (chemistry) chemistry.chemical_element General Chemistry Cyanation Copper Combinatorial chemistry Catalysis Surfaces Coatings and Films Electronic Optical and Magnetic Materials chemistry.chemical_compound chemistry Glycine Materials Chemistry Ceramics and Composites Organic synthesis |
| Zdroj: | Chemical communications (Cambridge, England). 57(24) |
| ISSN: | 1364-548X |
| Popis: | We report a catalytic oxidative C–H cyanation of glycine derivatives using a simple copper(I) catalyst with NFSI as an oxidant via a radical process to furnish α-cyano glycine derivatives, which are useful intermediates for organic synthesis. CuCl acted as both a one-electron reductant and a transition-metal catalyst in this transformation. NFSI served as a one-electron oxidant and generated a N-centered radical as a H-abstractor. The reaction displayed broad substrate scope and mild reaction conditions. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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