Prognostic value of mean velocity at the pulmonary artery estimated by cardiovascular magnetic resonance as a prognostic predictor in a cohort of patients with new-onset heart failure with reduced ejection fraction

Autor: Joaquina Belchi-Navarro, D. Perdomo-Londoño, José Leandro Pérez-Boscá, Óscar Fabregat-Andrés, A. Cubillos-Arango, Pilar García-González, Rafael Payá-Serrano, Blanca Trejo-Velasco, Mónica Ferrando-Beltrán, Francisco Ridocci-Soriano
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Male
lcsh:Diseases of the circulatory (Cardiovascular) system
Time Factors
030204 cardiovascular system & hematology
Ventricular Function
Left
0302 clinical medicine
Risk Factors
Clinical endpoint
030212 general & internal medicine
Prospective Studies
education.field_of_study
Ejection fraction
Radiological and Ultrasound Technology
Middle Aged
Prognosis
Cardiology
Disease Progression
Right ventricle
Female
Cardiology and Cardiovascular Medicine
Prognosis
pulmonary hypertension
Blood Flow Velocity
Research Article
medicine.medical_specialty
Hypertension
Pulmonary
Population
Magnetic Resonance Imaging
Cine
Pulmonary Artery
03 medical and health sciences
Predictive Value of Tests
Internal medicine
medicine.artery
medicine
Humans
Radiology
Nuclear Medicine and imaging
education
Cardiac MRI
Aged
Heart Failure
Ventricular-arterial coupling
Ischemic cardiomyopathy
business.industry
Surrogate endpoint
Stroke Volume
HFrEF
medicine.disease
Pulmonary hypertension
lcsh:RC666-701
Heart failure
Pulmonary artery
Ventricular Function
Right
business
human activities
Zdroj: Journal of Cardiovascular Magnetic Resonance
Journal of Cardiovascular Magnetic Resonance, Vol 22, Iss 1, Pp 1-13 (2020)
ISSN: 1532-429X
1097-6647
Popis: BackgroundPulmonary hypertension (PH) conveys a worse prognosis in heart failure (HF), in particular when right ventricular (RV) dysfunction ensues. Cardiovascular magnetic resonance (CMR) non-invasively estimates pulmonary vascular resistance (PVR), which has shown prognostic value in HF. Importantly, RV to pulmonary artery (PA) coupling is altered early in HF, before significant rise in PV resistance occurs. The aim of this study was to assess the prognostic value of mean velocity at the pulmonary artery (mvPA), a novel non-invasive parameter determined by CMR, in HF with reduced ejection fraction (HFrEF) with and without associated PH.MethodsProspective inclusion of 238 patients admitted for new-onset HFrEF. MvPA was measured with CMR during index admission. The primary endpoint was defined as a composite of HF readmissions and all-cause mortality.ResultsDuring a median follow-up of 25 months, 91 patients presented with the primary endpoint. Optimal cut-off value of mvPA calculated by the receiver operator curve for the prediction of the primary endpoint was 9 cm/s. The primary endpoint occurred more frequently in patients with mvPA≤9 cm/s, as indicated by Kaplan-Meier survival curves; Log Rank 16.0,p ConclusionsIn our HFrEF cohort, mvPA emerged as an independent prognostic indicator independent of RV function, allowing identification of a higher-risk population before structural damage onset. Moreover, mvPA emerged as a surrogate marker of the RV-PA unit coupling status.
Databáze: OpenAIRE
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