Acute promyelocytic leukemia presenting as recurrent venous and arterial thrombotic events: a case report and review of the literature
| Autor: | Maryam Rehan, Alexander Bershadskiy, Meena Kashi, Kira MacDougall, Divya Chukkalore |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Acute promyelocytic leukemia
venous thromboembolism Retinoic acid Case Report Chromosomal translocation chemistry.chemical_compound immune system diseases hemic and lymphatic diseases medicine ischemic stroke Alternation (formal language theory) neoplasms Internal medicine business.industry Myeloid leukemia acute promyelocytic leukemia medicine.disease RC31-1245 chemistry Ischemic stroke Cancer research splenic infarct renal infarct business Renal Infarct Venous thromboembolism all-transretinoic acid |
| Zdroj: | Journal of Community Hospital Internal Medicine Perspectives, Vol 11, Iss 6, Pp 832-838 (2021) Journal of Community Hospital Internal Medicine Perspectives article-version (VoR) Version of Record |
| ISSN: | 2000-9666 |
| Popis: | Acute promyelocytic leukemia (APL) is a distinct subtype of acute myeloid leukemia characterized by a translocation of chromosomes 15 and 17, creating an alternation in the retinoic acid receptor-alpha (RAR-alpha) gene. This leads to excessive medullary production of promyelocytic blasts, which are frequently associated with the hemorrhagic complications seen in APL. In contrast, APL-associated thrombosis occurs much less frequently and is an underappreciated life-threatening manifestation of the disease. Most thrombotic events occur during induction chemotherapy with all-transretinoic acid and are rarely seen as the initial presentation on APL. Here we report an exceedingly rare case of a patient with recurrent venous and arterial thrombotic events, including deep vein thrombosis, bilateral segmental pulmonary embolism, an ischemic stroke, splenic infarcts, and renal infarcts, later found to have APL. We aim to discuss the most recent understanding of the pathogenesis of APL-associated thrombosis and to summarize the literature of this rare presentation of APL. |
| Databáze: | OpenAIRE |
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