IGF-1, the cross road of the nutritional, inflammatory and hormonal pathways to frailty
| Autor: | G. Bondi, Francesca De Vita, Valeria Buttò, Fulvio Lauretani, Marcello Maggio, Gian Paolo Ceda, Antonio Nouvenne, Chiara Cattabiani, Elisabetta Dall'Aglio, Tiziana Meschi |
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| Rok vydání: | 2013 |
| Předmět: |
medicine.medical_specialty
Aging Anabolism Frail Elderly Nutritional Status lcsh:TX341-641 Inflammation Review frailty Biology magnesium Bioinformatics Selenium Internal medicine medicine Endocrine system Humans Insulin-Like Growth Factor I Aged Nutrition and Dietetics Stressor zinc Micronutrient Endocrinology Mobility Limitation Ageing ageing micronutrients IGF-1 Dietary Proteins medicine.symptom Energy Intake lcsh:Nutrition. Foods and food supply Biomarkers Food Science Hormone |
| Zdroj: | Nutrients Nutrients, Vol 5, Iss 10, Pp 4184-4205 (2013) |
| ISSN: | 2072-6643 |
| Popis: | The decline in functional capacity is a heterogeneous phenomenon in the elderly. An accelerated ageing determines a frail status. It results in an increased vulnerability to stressors for decreased physiological reserves. The early identification of a frail status is essential for preventing loss of functional capacity, and its clinical consequences. Frailty and mobility limitation result from an interplay of different pathways including multiple anabolic deficiency, inflammation, oxidative stress, and a poor nutritional status. However, the age-related decline in insulin-like growth factor 1 (IGF-1) bioactivity deserves special attention as it could represent the ideal crossroad of endocrine, inflammatory, and nutritional pathways to frailty. Several minerals, namely magnesium, selenium, and zinc, appear to be important determinants of IGF-1 bioactivity. This review aims to provide an overview of the potential usefulness of nutrients modulating IGF-1 as potential therapeutic targets in the prevention of mobility limitation occurring in frail older subjects. |
| Databáze: | OpenAIRE |
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