Wavelength-selective uncaging of dA and dC residues
| Autor: | Alexander Heckel, Florian Schäfer, Khashti Ballabh Joshi, Timo Mack, Josef Wachtveitl, Manuela A. H. Fichte |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Masking (art)
medicine.diagnostic_test Molecular Structure Chemistry Oligonucleotide Organic Chemistry Oligonucleotides Nanotechnology DNA Photochemistry medicine.disease_cause Photochemical Processes Biochemistry Wavelength Spectrophotometry medicine Molecule Spectrophotometry Ultraviolet Physical and Theoretical Chemistry Ultraviolet Benzofurans |
| Zdroj: | Organic letters. 13(6) |
| ISSN: | 1523-7052 |
| Popis: | Nitrodibenzofuran (NDBF) groups are used as photolabile “caging” groups to temporarily mask the Watson−Crick interaction of dA and dC residues. They show improved masking capabilities and are photodeprotected 12 times more efficiently than 1-(o-nitrophenyl)-ethyl (NPE) caging groups in these positions. Furthermore, NDBF groups can be removed wavelength-selectively in the presence of NPE groups. This will allow more complex (un)caging strategies of oligonucleotides − beyond the usual irreversible triggering. |
| Databáze: | OpenAIRE |
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