Does anticholinergics drug burden relate to global neuro-disability outcome measures and length of hospital stay?
| Autor: | Romain Buono, Mohamed Sakel, Jane Cross, Wei Yee Chan, Chris Fox, Alexis Boukouvalas, Toby O. Smith, Ian Maidment, Farhat Mirza, Phyo K. Myint, Maliha Moten |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Adult
Male Drug medicine.medical_specialty Traumatic brain injury medicine.drug_class medicine.medical_treatment media_common.quotation_subject Neuroscience (miscellaneous) Rehabilitation Centers Cholinergic Antagonists Outcome Assessment Health Care Developmental and Educational Psychology medicine Anticholinergic Humans Disabled Persons Adverse effect Spinal cord injury Spinal Cord Injuries Aged Retrospective Studies media_common Aged 80 and over Rehabilitation business.industry Outcome measures Recovery of Function Length of Stay Middle Aged medicine.disease Hospitalization Brain Injuries Physical therapy Female Neurology (clinical) business Hospital stay |
| ISSN: | 1362-301X |
| Popis: | Primary Objective: To assess the relationship between disability, length of stay (LOS) and anticholinergic burden (ACB) with people following acquired brain or spinal cord injury. Research Design: A retrospective case note review assessed total rehabilitation unit admission. Methods & Procedures: Assessment of 52 consecutive patients with acquired brain/spinal injury and neuropathy in an in-patient neuro-rehabilitation unit of a United Kingdom university hospital. Data analysed included: Northwick Park Dependency Score (NPDS), Rehabilitation complexity Scale (RCS), Functional Independence Measure and Functional Assessment Measure FIM-FAM (UK version 2.2), LOS and ACB. Outcome was different in RCS, NPDS and FIM-FAM between admission and discharge. Main Outcomes & Results: A positive change was reported in ACB results in a positive change in NPDS with no significant effect on FIM-FAM, either Motor or Cognitive, or on the RCS. Change in ACB correlated to the length of hospital stay (regression correlation: -6.64; SE: 3.89). There was a significant harmful impact of increase in ACB score during hospital stay, from low to high ACB on NPDS (OR=9.65; 95% CI: 1.36 to 68.64) and FIM-FAM Total scores (OR=0.03; 95% CI: 0.002 to 0.35). Conclusions: There was a statistically significant correlation of ACB and neuro-disability measures and LOS amongst this patient cohort. |
| Databáze: | OpenAIRE |
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