Evaluation of an Antioxidant and Anti-inflammatory Cocktail Against Human Hypoactivity-Induced Skeletal Muscle Deconditioning
| Autor: | Custaud, Marc-Antoine, Iwase, Satoshi, Stevens, Laurence, Arc-Chagnaud, Coralie, Py, Guillaume, Fovet, Théo, Roumanille, Rémi, Demangel, Rémi, Pagano, Allan, Delobel, Pierre, Blanc, Stéphane, Jasmin, Bernard, Blottner, Dieter, Salanova, Michele, Gomez-Cabrera, Mari-Carmen, Viña, José, BRIOCHE, THOMAS, CHOPARD, Angèle |
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| Přispěvatelé: | Raynaud, Christelle, Universitat de València (UV), Dynamique Musculaire et Métabolisme (DMEM), Université de Montpellier (UM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Université de Strasbourg (UNISTRA), University of Ottawa [Ottawa], Institut Pluridisciplinaire Hubert Curien (IPHC), Université de Strasbourg (UNISTRA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], Dept Physiol, Freshage Res Grp, CIBERFES,INCLIVA, Universidad de Valencia, Centre National d'Etudes Spatiales (CNES), Canadian Space Agency, Helmholtz Association German Aerospace Centre (DLR) 50WB1121-1421, Biologie Neurovasculaire et Mitochondriale Intégrée (BNMI), Université d'Angers (UA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Unité de Recherche Pluridisciplinaire Sport, Santé, Société (URePSSS) - ULR 7369 - ULR 4488 (URePSSS), Université d'Artois (UA)-Université de Lille-Université du Littoral Côte d'Opale (ULCO), University of Ottawa [Ottawa] (uOttawa), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Charité - Universitätsmedizin Berlin / Charite - University Medicine Berlin |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Physiology medicine.medical_treatment [SDV]Life Sciences [q-bio] Context (language use) Sciences du Vivant [q-bio]/Médecine humaine et pathologie Bed rest medicine.disease_cause lcsh:Physiology 03 medical and health sciences Sciences du Vivant [q-bio]/Autre [q-bio.OT] 0302 clinical medicine Atrophy Deconditioning Internal medicine Physiology (medical) medicine oxidative stress cell signaling Wasting Original Research [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology lcsh:QP1-981 business.industry Skeletal muscle muscle wasting medicine.disease 3. Good health [SDV] Life Sciences [q-bio] 030104 developmental biology Endocrinology medicine.anatomical_structure antioxidants inactivity Fisiologia humana medicine.symptom business Hypoactivity 030217 neurology & neurosurgery Oxidative stress [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology |
| Zdroj: | Arc Chagnaud, Coralie Py, Guillaume Fovet, Theo Roumanille, Remi Demangel, Remi Pagano, Allan F. Delobel, Pierre Blanc, Stephane Jasmin, Bernard J. Blottner, Dieter Salanova, Michele Gomez Cabrera, M.C. Viña Ribes, José Brioche, T. Chopard, A. 2020 Evaluation of an Antioxidant and Anti-inflammatory Cocktail Against Human Hypoactivity-Induced Skeletal Muscle Deconditioning Frontiers In Physiology Feb 12 11 71 Frontiers in Physiology Frontiers in Physiology, 2020, 11, ⟨10.3389/fphys.2020.00071⟩ RODERIC. Repositorio Institucional de la Universitat de Valéncia instname Frontiers in Physiology, Frontiers, 2020, 11, ⟨10.3389/fphys.2020.00071⟩ RODERIC: Repositorio Institucional de la Universitat de Valéncia r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA Frontiers in Physiology, Vol 11 (2020) |
| ISSN: | 1664-042X |
| Popis: | International audience; Understanding the molecular pathways involved in the loss of skeletal muscle mass and function induced by muscle disuse is a crucial issue in the context of spaceflight as well as in the clinical field, and development of efficient countermeasures is needed. Recent studies have reported the importance of redox balance dysregulation as a major mechanism leading to muscle wasting. Our study aimed to evaluate the effects of an antioxidant/anti-inflammatory cocktail (741 mg of polyphenols, 138 mg of vitamin E, 80 mu g of selenium, and 2.1 g of omega-3) in the prevention of muscle deconditioning induced by long-term inactivity. The study consisted of 60 days of hypoactivity using the head-down bed rest (HDBR) model. Twenty healthy men were recruited; half of them received a daily antioxidant/anti-inflammatory supplementation, whereas the other half received a placebo. Muscle biopsies were collected from the vastus lateralis muscles before and after bedrest and 10 days after remobilization. After 2 months of HDBR, all subjects presented muscle deconditioning characterized by a loss of muscle strength and an atrophy of muscle fibers, which was not prevented by cocktail supplementation. Our results regarding muscle oxidative damage, mitochondrial content, and protein balance actors refuted the potential protection of the cocktail during long-term inactivity and showed a disturbance of essential signaling pathways (protein balance and mitochondriogenesis) during the remobilization period. This study demonstrated the ineffectiveness of our cocktail supplementation and underlines the complexity of redox balance mechanisms. It raises interrogations regarding the appropriate nutritional intervention to fight against muscle deconditioning. |
| Databáze: | OpenAIRE |
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