Sarcopenia is a predictive factor of poor quality of life and prognosis in patients after radical gastrectomy
| Autor: | Feng-Min Zhang, Zi-Le Shen, Xia-Lin Yan, Hong-Bo Zou, Li-Ping Zhou, Zhen Yu, Cheng-Le Zhuang, Wen-Xi Dong, Ding-Ye Yu, Guo-Jun Cai |
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| Rok vydání: | 2021 |
| Předmět: |
Male
Sarcopenia medicine.medical_specialty Adenocarcinoma Anxiety 03 medical and health sciences Postoperative Complications 0302 clinical medicine Quality of life Gastrectomy Stomach Neoplasms Internal medicine medicine Humans 030212 general & internal medicine Risk factor Aged Neoplasm Staging Aged 80 and over Radical gastrectomy business.industry Incidence (epidemiology) Cancer Health Care Costs General Medicine Middle Aged Prognosis medicine.disease humanities Predictive factor Survival Rate Oncology 030220 oncology & carcinogenesis Quality of Life Female Surgery medicine.symptom business human activities |
| Zdroj: | European Journal of Surgical Oncology. 47:1976-1984 |
| ISSN: | 0748-7983 |
| DOI: | 10.1016/j.ejso.2021.03.004 |
| Popis: | Background Patients with gastric cancer often suffer from generalized and progressive reduction of skeletal muscle mass and strength, which negatively affects the quality of life (QOL). In this study, we explored the impact of sarcopenia on QOL and overall survival (OS). Methods From December 2015 to June 2017, 135 patients underwent radical gastrectomy at the First Affiliated Hospital of Wenzhou Medical University. Based on the diagnostic criteria of the Asian Working Group for Sarcopenia (AWGS), data including handgrip strength, 6-m gait speed and muscle mass were collected and analyzed. EORTC QLQ-C30 and EORTC QLQ-STO22 were used to evaluate the QOL before surgery, 1, 3 and 6 months after surgery. Results A total of 27 out of the 135 patients (20.00%) were diagnosed with sarcopenia. Compared with non-sarcopenia group, patients in sarcopenia group had a higher incidence of postoperative complications (14.80% vs. 40.70%, p = 0.003), and more hospitalization costs (p = 0.029). The scores of eating restriction (p = 0.026), anxiety (p = 0.045) and body image (p = 0.046) were significantly higher in sarcopenia group at postoperative 6 months. Besides, sarcopenia was an independent risk factor for global health status at 6 months after operation (OR: 2.881, 95% CI: 1.110–7.475, p = 0.030) and OS (HR: 3.140, 95% CI: 1.255–7.855, p = 0.014). Other factors, including tumor stage III and the postoperative complications, had negative influences on OS. Conclusion Sarcopenia is a predictive factor of poor QOL and prognosis in patients with gastric cancer. |
| Databáze: | OpenAIRE |
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