Ephs and Ephrins in Cancer: Ephrin-A1 Signaling
| Autor: | Amanda Beauchamp, Waldemar Debinski |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
MAPK/ERK pathway
rho GTP-Binding Proteins animal structures Biology Article Cell Physiological Phenomena Neovascularization Neoplasms medicine Ephrin Animals Humans PI3K/AKT/mTOR pathway Cytoskeleton Neovascularization Pathologic Receptor EphA2 Erythropoietin-producing hepatocellular (Eph) receptor Cancer Endothelial Cells Ephrin-A1 Cell Biology medicine.disease EPH receptor A2 biological factors Cell biology Protein Structure Tertiary nervous system embryonic structures sense organs medicine.symptom Signal transduction Developmental Biology Signal Transduction |
| Popis: | Ephrin-A1 and its primary receptor, EphA2, are involved in numerous physiological processes and have been intensely studied for their roles in malignancy. Ephrin-Eph signalling is complex on its own and is also cell-type dependent, making elucidation of the exact role of ephrin-A1 in neoplasia challenging. Multiple oncogenic signalling pathways, such as MAP/ERK and PI3K are affected by ephrin-A1, and in some cases evidence suggests the promotion of a specific pathway in one cell or cancer type and inhibition of the same pathway in another type of cell or cancer. Ephrin-A1 also plays an integral role in angiogenesis and tumor neovascularization. Until recently, studies investigating ephrins focused on the ligands as GPI-anchored proteins that required membrane anchoring or artificial clustering for Eph receptor activation. However, recent studies have demonstrated a functional role for soluble, monomeric ephrin-A1. This review will focus on various forms of ephrin-A1-specific signalling in human malignancy. |
| Databáze: | OpenAIRE |
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