Alteration of brain temperature and systemic inflammation in Parkinson’s disease

Autor: Wei-Che Lin, Hsiu-Ling Chen, Cheng-Hsien Lu, Koji Sakai, Meng-Hsiang Chen, Kei Yamada
Rok vydání: 2020
Předmět:
Male
0301 basic medicine
medicine.medical_specialty
Parkinson's disease
Neurology
Mitochondrial disease
Diffusion-weighted MRI
Autonomic diseases
Thermometry
Dermatology
Systemic inflammation
medicine.disease_cause
Gastroenterology
Body Temperature
Pathogenesis
03 medical and health sciences
0302 clinical medicine
Internal medicine
Humans
Medicine
Neuroinflammation
Aged
Retrospective Studies
Inflammation
Mitochondrial disorders
medicine.diagnostic_test
business.industry
Brain
Parkinson Disease
Magnetic resonance imaging
General Medicine
Middle Aged
medicine.disease
Psychiatry and Mental health
Cross-Sectional Studies
Diffusion Magnetic Resonance Imaging
030104 developmental biology
Oxidative stress
Original Article
Female
Neurology (clinical)
medicine.symptom
business
030217 neurology & neurosurgery
Zdroj: Neurological Sciences
ISSN: 1590-3478
1590-1874
Popis: Objectives Parkinson’s disease (PD) is known to be related to various factors, including neuroinflammation, increased oxidative stress, and brain temperature alteration. We aimed to evaluate the correlation between these factors using diffusion-weighted imaging (DWI) thermometry and blood tests of systemic inflammation. Methods From July 2012 to Jun 2017, 103 patients with PD (44 men and 59 women; mean age, 60.43 ± 9.12 years) and 106 sex- and age-matched healthy volunteers (48 men and 58 women; mean age, 58.16 ± 8.45 years) retrospectively underwent magnetic resonance DWI thermometry to estimate brain intraventricular temperature (Tv). Subjects were divided into three subgroups in light of their ages. The tested inflammatory markers included plasma nuclear DNA, mitochondrial DNA, apoptotic leukocytes, and serum adhesion molecules. The correlations among the Tv values, clinical severity, and systemic inflammatory markers were then calculated. Results The PD patients did not show a natural trend of decline in Tv with age. Comparisons among the different age groups revealed that the younger PD subjects had significantly lower Tv values than the younger controls, but the older subjects had no significant group differences. Overall, the PD patients exhibited lower Tv values than the controls, as well as increased oxidative stress. The brain temperature showed positive correlations with inflammatory markers, including plasma nuclear DNA and L-selectin levels, in all the subjects. Conclusions Possible pathophysiological correlations between systemic inflammation and brain temperature were indicated by the results of this study, a finding which may aid us in investigating the underlying pathogenesis of PD.
Databáze: OpenAIRE
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