Optofluidic bioanalysis: fundamentals and applications
| Autor: | Aaron R. Hawkins, Hong Cai, Holger Schmidt, Kaelyn D. Leake, Damla Ozcelik |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Bioanalysis
Computer science QC1-999 Interface (computing) Microfluidics photonics 02 engineering and technology 01 natural sciences Article Optofluidics law.invention 010309 optics Software portability law 0103 physical sciences Fluidics Electrical and Electronic Engineering business.industry optofluidics Physics Lab-on-a-chip 021001 nanoscience & nanotechnology Atomic and Molecular Physics and Optics lab-on-chip Electronic Optical and Magnetic Materials integrated optics Systems engineering biosensing Photonics 0210 nano-technology business Biotechnology |
| Zdroj: | Nanophotonics, Vol 6, Iss 4, Pp 647-661 (2017) |
| ISSN: | 2192-8614 2192-8606 |
| DOI: | 10.1515/nanoph-2016-0156 |
| Popis: | Over the past decade, optofluidics has established itself as a new and dynamic research field for exciting developments at the interface of photonics, microfluidics, and the life sciences. The strong desire for developing miniaturized bioanalytic devices and instruments, in particular, has led to novel and powerful approaches to integrating optical elements and biological fluids on the same chip-scale system. Here, we review the state-of-the-art in optofluidic research with emphasis on applications in bioanalysis and a focus on waveguide-based approaches that represent the most advanced level of integration between optics and fluidics. We discuss recent work in photonically reconfigurable devices and various application areas. We show how optofluidic approaches have been pushing the performance limits in bioanalysis, e.g. in terms of sensitivity and portability, satisfying many of the key requirements for point-of-care devices. This illustrates how the requirements for bianalysis instruments are increasingly being met by the symbiotic integration of novel photonic capabilities in a miniaturized system. |
| Databáze: | OpenAIRE |
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