The effect of 6 weeks of testosterone treatment on pulsatile luteinizing hormone secretion in eugonadal female-to-male transsexuals
| Autor: | Fedde Scheele, Peter G.A. Hompes, Louis Gooren, Jan J. Spijkstra, Taeke Spinder |
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| Přispěvatelé: | IOO, Other Research, Obstetrics and gynaecology, Internal medicine, Intensive care medicine |
| Rok vydání: | 1991 |
| Předmět: |
medicine.medical_specialty
medicine.drug_class Estrone Radioimmunoassay chemistry.chemical_compound Internal medicine medicine Humans Testosterone Luteinizing hormone secretion business.industry Obstetrics and Gynecology General Medicine Luteinizing Hormone Androgen Gonadotropin secretion Polycystic ovarian disease Endocrinology Reproductive Medicine chemistry Pulsatile Flow Female Luteinizing hormone business Transsexualism Hormone |
| Zdroj: | Scheele, F, Hompes, P G A, Gooren, L J G, Spijkstra, J J & Spinder, T 1991, ' The effect of 6 weeks of testosterone treatment on pulsatile luteinizing hormone secretion in eugonadal female-to-male transsexuals ', Fertility and Sterility, vol. 55, no. 3, pp. 608-611 . https://doi.org/10.1016/S0015-0282(16)54194-6 Fertility and Sterility, 55(3), 608-611. Elsevier Inc. |
| ISSN: | 0015-0282 |
| Popis: | Polycystic ovary disease generally is associated with elevated androgen levels and elevated luteinizing hormone (LH) levels, whereas follicle-stimulating hormone (FSH) levels are (sub)normal. To assess the role of androgens on gonadotropin secretion, we investigated the effect of 6 weeks of testosterone (T) undecanoate, 120 to 160 mg/d orally, on the parameters of the pulsatile secretion of LH in a group of six eugonadal female-to-male transsexuals with normal menstrual cycles. The treatment suppressed menstrual activity in all patients. Serum T and estrone were significantly elevated after treatment with oral T undecanoate. The parameters of the pulsatile secretion of LH were not affected by androgen administration. Levels of FSH, estradiol, and progesterone also did not change significantly. |
| Databáze: | OpenAIRE |
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