Birth weight, working memory and epigenetic signatures in IGF2 and related genes: a MZ twin study

Autor: Silvia Alemany, Mar Fatjó-Vilas, Juan C. Leza, Lourdes Fañanás, Ana González-Pinto, Igor Nenadic, Aldo Córdova-Palomera, Ximena Goldberg
Přispěvatelé: Universitat de Barcelona
Rok vydání: 2014
Předmět:
BIOCHEMISTRY AND MOLECULAR BIOLOGY
ADN
Neurodevelopment
Epigenesis
Genetic
Cognition
imprinting control region
Pregnancy
Morphogenesis
Medicine and Health Sciences
Birth Weight
folic-acid use
Genetics
Multidisciplinary
Mosaicism
beta-actin synthesis
Methylation
Memory
Short-Term
Neurology
CpG site
AGRICULTURAL AND BIOLOGICAL SCIENCES
DNA methylation
DNA methilation
Female
Epigenetics
Research Article
Science
Birth weight
mouse model
Neuropsychiatric Disorders
Biology
Neurologia
binding-protein 1
Developmental Neuroscience
Memory
Insulin-Like Growth Factor II
human genome
Mental Health and Psychiatry
Humans
Stochastic Processes
MEDICINE
growth-factor 2
Cognitive Psychology
Biology and Life Sciences
DNA
Twins
Monozygotic
DNA Methylation
Twin study
adult hippocampal neurogenesis
schizophrenia
Prenatal stress
Neurodevelopmental Disorders
Cognitive Science
Neurocognitive
Memòria
Developmental Biology
Neuroscience
Zdroj: PLoS ONE
Addi. Archivo Digital para la Docencia y la Investigación
instname
Recercat. Dipósit de la Recerca de Catalunya
Dipòsit Digital de la UB
Universidad de Barcelona
PLoS ONE, Vol 9, Iss 8, p e103639 (2014)
ISSN: 1932-6203
Popis: Neurodevelopmental disruptions caused by obstetric complications play a role in the etiology of several phenotypes associated with neuropsychiatric diseases and cognitive dysfunctions. Importantly, it has been noticed that epigenetic processes occurring early in life may mediate these associations. Here, DNA methylation signatures at IGF2 (insulin-like growth factor 2) and IGF2BP1-3 (IGF2-binding proteins 1-3) were examined in a sample consisting of 34 adult monozygotic (MZ) twins informative for obstetric complications and cognitive performance. Multivariate linear regression analysis of twin data was implemented to test for associations between methylation levels and both birth weight (BW) and adult working memory (WM) performance. Familial and unique environmental factors underlying these potential relationships were evaluated. A link was detected between DNA methylation levels of two CpG sites in the IGF2BP1 gene and both BW and adult WM performance. The BW-IGF2BP1 methylation association seemed due to non-shared environmental factors influencing BW, whereas the WM-IGF2BP1 methylation relationship seemed mediated by both genes and environment. Our data is in agreement with previous evidence indicating that DNA methylation status may be related to prenatal stress and later neurocognitive phenotypes. While former reports independently detected associations between DNA methylation and either BW or WM, current results suggest that these relationships are not confounded by each other. This work is supported by the Spanish SAF2008-05674-C03-01, European Twins Study Network on Schizophrenia Research Training Network (grant number EUTwinsS; MRTN-CT-2006-035987; local PIs: F.L. and N.I.), the Catalan 2014SGR1636 and the Ministry of Science and Innovation (PIM2010ERN-00642) in frame of ERA-NET NEURON. A.C.P. was funded by CONACyT (Mexico). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Databáze: OpenAIRE
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