Combining serum 1,5-anhydroglucitol with fasting plasma glucose to detect diabetes mellitus in a community-based population with hypertension
| Autor: | Yuexing Yuan, Jinfeng Cheng, Yao Wang, Cheng Chen |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Blood Glucose
medicine.medical_specialty Population Type 2 diabetes Deoxyglucose Gastroenterology chemistry.chemical_compound Internal medicine Diabetes mellitus Diabetes Mellitus medicine Humans education Advanced and Specialized Nursing education.field_of_study Receiver operating characteristic business.industry Area under the curve Fasting medicine.disease Confidence interval Anesthesiology and Pain Medicine Postprandial chemistry Hypertension 1 5-Anhydroglucitol business |
| Zdroj: | Annals of Palliative Medicine. 10:8746-8752 |
| ISSN: | 2224-5839 2224-5820 |
| DOI: | 10.21037/apm-21-1305 |
| Popis: | BACKGROUND: The early diagnosis and treatment of diabetes mellitus has significant clinical benefits. However, the current diagnostic tools available for community-based populations are limited. This study sought to evaluate the clinical benefits of combining serum 1,5-anhydroglucitol (1,5-AG) with fasting plasma glucose (FPG) to detect diabetes in a community-based population with hypertension. METHODS: A total of 359 subjects were enrolled in this diagnostic study, all of whom underwent a 75-g oral glucose tolerance test (OGTT). Venous blood samples were collected to measure FPG, 2 h postprandial plasma glucose (2h-PG), and hemoglobin A1c (HbA1c). Serum 1,5-AG levels were tested using the Glycomark assay, and a receiver operating characteristic (ROC) curve was used to assess the diagnostic value of this tool for diabetes and determine the optimal cut-point value to provide the maximum Youden's index. A Spearman correlation analysis was performed to analyze the relationship between 1,5-AG and other indexes. RESULTS: A total of 102 participants were diagnosed with diabetes, indicating a prevalence of 28.4% in the community-based population. The Spearman correlation analysis showed that 1,5-AG was negatively correlated with FPG and 2h-PG (r=-0.367 and -0.487, respectively; both P |
| Databáze: | OpenAIRE |
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