Association of glomerular hyperfiltration with serum chemokine levels and metabolic features in prepubertal children with overweight/obesity

Autor: Silvia Martina Ferrari, Yanina Morosán-Allo, María Laura Kabakian, Poupak Fallahi, Gabriela Brenta, María Pía Santucci, Cristina Andres-Lacueva, Alessandro Antonelli, Jorgelina Fernández, María Luz Muzzio, Tomás Meroño
Rok vydání: 2019
Předmět:
Male
Pediatric Obesity
Endocrinology
Diabetes and Metabolism
Hyperfiltration
Medicine (miscellaneous)
030204 cardiovascular system & hematology
Overweight
Fatty Acids
Nonesterified
Kidney
chemistry.chemical_compound
0302 clinical medicine
Child Development
Risk Factors
Prospective Studies
Child
Children
Nutrition and Dietetics
Kidney diseases
Age Factors
CXCL9
Female
Kidney Diseases
medicine.symptom
Chemokines
Cardiology and Cardiovascular Medicine
Glomerular hyperfiltration
Glomerular Filtration Rate
medicine.medical_specialty
030209 endocrinology & metabolism
CCL5
Renal disease
03 medical and health sciences
NEFA
Diabetes mellitus
Internal medicine
medicine
Humans
Obesity
Interleukin 8
Obesitat en els infants
business.industry
medicine.disease
Endocrinology
Obesity in children
Cross-Sectional Studies
chemistry
Uric acid
Malalties del ronyó
business
Energy Metabolism
Biomarkers
Zdroj: Dipòsit Digital de la UB
Universidad de Barcelona
ISSN: 1590-3729
Popis: Background and aims Glomerular hyperfiltration (GH) is proposed as one of the earliest events in obesity (OB)-associated renal disease. Children with GH and type-1 diabetes showed increased chemokine levels. Chemokine associations with glomerular filtration rate (GFR) and metabolic features in prepubertal children with overweight (OW)/OB are unknown. Methods and results Cross-sectional study. 75 prepubertal children (aged: 9.0 ± 1.7 years) with OW/OB were studied. Clinical and metabolic characteristics (including non-esterified fatty acids, NEFA) and GFR (combined Zappitelli equation) were assessed. GH was defined as GFR >135 ml/min.1.73 m2. Serum levels of regulated on activation, normal T cell expressed and secreted (RANTES)/CCL5, interleukin-8 (IL-8)/CXCL8 and monokine-induced by interferon-γ (MIG)/CXCL9 were measured by ELISA. Age- and sex-adjusted correlations and differences were tested. 48% of the cohort was female and 13% were OW, 54% OB and 33% severe OB. Prepubertal children with GH showed lower z-BMI (−12%), NEFA (−26%) and uric acid (−22%) than those without GH (all p < 0.05). Similarly to high sensitivity C-reactive protein (hsCRP), there were no differences in serum chemokines between children with GH or not (all p > 0.05). Adjusted correlations were significant for RANTES and z-BMI (r = 0.26; p < 0.05) and for MIG with z-BMI (r = −0.26; p < 0.05) and with NEFA (r = 0.27; p < 0.05). Conclusion GH was not associated with higher chemokine levels in prepubertal children with OW/OB. Decreased rather than elevated GFR values were correlated with obesity and worse metabolic profiles. Chemokines levels in children with severe OB suggest a regulation of the immune response. Follow-up studies are needed to address the clinical implications of these findings. Keywords ObesityChildrenChemokinesHyperfiltrationRenal disease
Databáze: OpenAIRE
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