Mucoadhesive paclitaxel-loaded chitosan-poly (isobutyl cyanoacrylate) core-shell nanocapsules containing copaiba oil designed for oral drug delivery
| Autor: | Claire Gueutin, Eryvaldo Sócrates Tabosa do Egito, Christine Vauthier, Francisco Humberto Xavier-Jr., Hélène Chacun |
|---|---|
| Přispěvatelé: | Institut Galien Paris-Sud (IGPS), Université Paris-Sud - Paris 11 (UP11)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS) |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Chromatography
Ussing chamber Chemistry Pharmaceutical Science 02 engineering and technology 021001 nanoscience & nanotechnology 030226 pharmacology & pharmacy Copaiba Oil Nanocapsules 3. Good health Chitosan 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine [SDV.SP.PG]Life Sciences [q-bio]/Pharmaceutical sciences/Galenic pharmacology Paclitaxel Intestinal mucosa Drug delivery Mucoadhesion 0210 nano-technology [SDV.IB.BIO]Life Sciences [q-bio]/Bioengineering/Biomaterials ComputingMilieux_MISCELLANEOUS |
| Zdroj: | Journal of Drug Delivery Science and Technology Journal of Drug Delivery Science and Technology, Elsevier, 2019, 53, pp.101194. ⟨10.1016/j.jddst.2019.101194⟩ |
| ISSN: | 1773-2247 |
| DOI: | 10.1016/j.jddst.2019.101194⟩ |
| Popis: | The development of drug delivery systems for potent anticancer drugs like paclitaxel remains a challenger. The aim of this work was to study the mucoadhesive properties of paclitaxel-loaded chitosan-poly (isobutyl cyanoacrylate) core-shell nanocapsules designed for oral drug delivery. Using an experimental design approach, the nanocapsules were produced and, then, physicochemically characterized. Mucoadhesion assays were performed in-vitro by the aggregation test with mucin and ex-vivo, in Ussing Chamber, using freshly excised rat intestinal mucosa. [3H]-paclitaxel dosages were carried out by liquid scintillation. Paclitaxel-loaded nanocapsules showed a mean hydrodynamic diameter of 470 nm with low polydispersity index and spherical form. Encapsulation efficiency and drug loading of paclitaxel were 74 ± 1% and 1.70 ± 0.02%, respectively. After drying, nanocapsules could be redispersed with no changes on their nanostructure. Dispersions of nanocapsules were stable in simulated gastric medium for 120 min, and after six months of storage at 4 °C. They showed interesting mucoadhesive properties with mucins and good association (9%) with the intestinal mucosa of the rat. Taking together, results from the present work are encouraging to pursue the development of chitosan-coated nanocapsules for oral delivery of paclitaxel as a new treatment for cancer with possible synergetic anticancer effect with the therapeutically active components found in copaiba oil. |
| Databáze: | OpenAIRE |
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