Association of MTHFR C677T and A1298C gene polymorphisms with methotrexate efficiency and toxicity in Algerian rheumatoid arthritis patients
| Autor: | Soraya Mouaki Benani, Ines Allam, Reda Djidjik, Fadia Rahal, Aïcha Laadjouz, Lilya Berkani |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
musculoskeletal diseases medicine.medical_specialty Pharmacology Gastroenterology Article 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Genetics Clinical genetics Allele lcsh:Social sciences (General) Adverse effect skin and connective tissue diseases lcsh:Science (General) Genotyping 030203 arthritis & rheumatology Multidisciplinary biology business.industry Health sciences medicine.disease 030104 developmental biology Methylenetetrahydrofolate reductase Rheumatoid arthritis Toxicity biology.protein Methotrexate lcsh:H1-99 Gene polymorphism business medicine.drug lcsh:Q1-390 |
| Zdroj: | Heliyon, Vol 3, Iss 11, Pp e00467-(2017) Heliyon |
| ISSN: | 2405-8440 |
| Popis: | Methotrexate (MTX) is the most used drug in rheumatoid arthritis (RA) treatment. However, it shows variability in clinical response, which is explained by an association with genetic polymorphisms. This study aimed to elucidate the role of the two gene polymorphism C677T and A1298C of the methylenetetrahydrofolate reductase (MTHFR) in response to MTX in Algerian RA patients. Study included 54 early RA patient treated with MTX for one year. MTX efficiency and toxicity were evaluated at 6 and 12 months respectively and the two gene polymorphisms were genotyped. No association was found between A1298C polymorphism and MTX toxicity. However, T allele of the C677T polymorphism was associated with the occurrence of MTX adverse effects (p = 0,019, OR: 3,63, 95% CI [1,12 - 12,80]). No association was found between C677T polymorphism and MTX efficiency, while A allele of the A1298C polymorphism was associated with good and moderate response (p = 0,02, OR = 3,28, 95% CI: [1,11– 9,42]). The study of RA biological markers kinetics showed that MTX did not affect antibodies rate unlike inflammatory markers. Our study suggests that MTHFR C677T and A1298C genotyping are associated to MTX toxicity and efficiency, respectively, in RA patients. This offers new perspectives in the personalization of RA treatment in Algeria. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|