Calcium phosphate porous pellets as drug delivery systems : effect of drug carrier composition on drug loading and in vitro release
| Autor: | Dominique Chulia, Maggy Dutreih-Colas, Chantal Damia, Marylène Viana, Eric Champion, Hiva Baradari, Etienne Laborde, Nathalie Pécout |
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| Přispěvatelé: | Axe 1 : procédés céramiques, Science des Procédés Céramiques et de Traitements de Surface (SPCTS), Université de Limoges (UNILIM)-Ecole Nationale Supérieure de Céramique Industrielle (ENSCI)-Institut des Procédés Appliqués aux Matériaux (IPAM), Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Limoges (UNILIM)-Ecole Nationale Supérieure de Céramique Industrielle (ENSCI)-Institut des Procédés Appliqués aux Matériaux (IPAM), Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Axe 3 : organisation structurale multiéchelle des matériaux |
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Materials science
Beta tricalcium phosphate Drug delivery system Pellets chemistry.chemical_element Ibuprofen 02 engineering and technology Calcium Pharmacology 010402 general chemistry 01 natural sciences Hydroxyapatite Porous pellets chemistry.chemical_compound Adsorption stomatognathic system Materials Chemistry medicine organic chemicals digestive oral and skin physiology 021001 nanoscience & nanotechnology Phosphate equipment and supplies 0104 chemical sciences Targeted drug delivery chemistry Drug delivery Ceramics and Composites 0210 nano-technology Drug carrier medicine.drug Nuclear chemistry |
| Zdroj: | Journal of the European Ceramic Society Journal of the European Ceramic Society, Elsevier, 2012, 32, pp.2679-2690. ⟨10.1016/j.jeurceramsoc.2012.01.018⟩ |
| ISSN: | 0955-2219 |
| DOI: | 10.1016/j.jeurceramsoc.2012.01.018⟩ |
| Popis: | Drug loaded porous calcium phosphate bone substitutes are studied for targeted drug delivery applications. In this study, porous hydroxyapatite and beta-tricalcium phosphate pellets were investigated as anti-inflammatory drug carriers and their ibuprofen adsorption and release properties were compared. While the adsorption equilibrium time of 1 h was obtained for both pellets, hydroxyapatite pellets showed a higher adsorption capacity than beta-tricalcium phosphate. The physico-chemical characterisations of loaded pellets confirmed an ibuprofen reversible physisorption on both hydroxyapatite and beta-tricalcium phosphate pellets. Moreover, higher adsorption capacity of hydroxyapatite was attributed to their physical differences. The in vitro ibuprofen release evaluation showed 100% release of ibuprofen from both hydroxyapatite and beta-tricalcium phosphate pellets which was found to be compatible with the obtained interactions between the pellets and ibuprofen. © 2012 Elsevier Ltd. All rights reserved. |
| Databáze: | OpenAIRE |
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