The pericentromeric heterochromatin of homologous chromosomes remains associated after centromere pairing dissolves in mouse spermatocyte meiosis
Autor: | Dean S. Dawson, Chih-Ying Lee, Roberto J. Pezza, Craig Eyster, Hoa H. Chuong |
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Rok vydání: | 2019 |
Předmět: |
Male
Chromocenter Heterochromatin Centromere Spermatocyte Biology Prophase Mice 03 medical and health sciences 0302 clinical medicine Meiosis Spermatocytes Chromosome Segregation Genetics Homologous chromosome medicine Animals Genetics (clinical) 030304 developmental biology Anaphase Recombination Genetic 0303 health sciences Chromosome Centromere-pairing Cell biology Chromosome Pairing medicine.anatomical_structure Original Article SYCP1 030217 neurology & neurosurgery |
Zdroj: | Chromosoma |
ISSN: | 1432-0886 0009-5915 |
Popis: | In meiosis, crossovers between homologous chromosomes link them together. This enables them to attach to microtubules of the meiotic spindle as a unit, such that the homologs will be pulled away from one another at anaphase I. Homologous pairs can sometimes fail to become linked by crossovers. In some organisms, these non-exchange partners are still able to segregate properly. In several organisms, associations between the centromeres of non-exchange partners occur in meiotic prophase. These associations have been proposed to promote segregation in meiosis I. But it is unclear how centromere pairing could promote subsequent proper segregation. Here we report that meiotic centromere pairing of chromosomes in mouse spermatocytes allows the formation of an association between chromosome pairs. We find that heterochromatin regions of homologous centromeres remain associated even after centromere-pairing dissolves. Our results suggest the model that, in mouse spermatocytes, heterochromatin maintains the association of homologous centromeres in the absence crossing-over. Electronic supplementary material The online version of this article (10.1007/s00412-019-00708-6) contains supplementary material, which is available to authorized users. |
Databáze: | OpenAIRE |
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