Clear cell odontogenic carcinoma
| Autor: | Rob Vogels, Marian A. J. Verdijk, Elisabeth Bloemena, Daniel Baumhoer, Maria Debiec-Rychter, Pieter J. Slootweg, Astrid Eijkelenboom, Patricia van Cleef, Joost van Gorp, Bjorn Lohman, Uta Flucke |
|---|---|
| Přispěvatelé: | Maxillofacial Surgery (VUmc), Pathology, AGEM - Digestive immunity, CCA - Cancer Treatment and quality of life |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Male Pathology medicine.medical_specialty Oncogene Proteins Fusion Odontogenic Tumors Biology Rare cancers Radboud Institute for Molecular Life Sciences [Radboudumc 9] Pathology and Forensic Medicine Fusion gene 03 medical and health sciences 0302 clinical medicine All institutes and research themes of the Radboud University Medical Center medicine Humans SDG 14 - Life Below Water Hyalinizing clear cell carcinoma Gene Clear cell odontogenic carcinoma Aged Original Paper Salivary gland ATF1 Middle Aged medicine.disease Jaw Neoplasms 030104 developmental biology Real-time polymerase chain reaction medicine.anatomical_structure Oncology Otorhinolaryngology 030220 oncology & carcinogenesis biology.protein Female CREB1 Rare cancers Radboud Institute for Health Sciences [Radboudumc 9] |
| Zdroj: | Vogels, R, Baumhoer, D, van Gorp, J, Eijkelenboom, A, Verdijk, M, van Cleef, P, Bloemena, E, Slootweg, P J, Lohman, B, Debiec-Rychter, M & Flucke, U 2019, ' Clear cell odontogenic carcinoma : Occurrence of EWSR1-CREB1 as alternative fusion gene to EWSR1-ATF1 ', Head and Neck Pathology, vol. 13, no. 2, pp. 225-230 . https://doi.org/10.1007/s12105-018-0953-z Head and Neck Pathology, 13, 225-230 Head and Neck Pathology, 13(2), 225-230. Humana Press Head and neck pathology, 13(2), 225-230. Humana Press Vogels, R, Baumhoer, D, van Gorp, J, Eijkelenboom, A, Verdijk, M, van Cleef, P, Bloemena, E, Slootweg, P J, Lohman, B, Debiec-Rychter, M & Flucke, U 2019, ' Clear Cell Odontogenic Carcinoma : Occurrence of EWSR1-CREB1 as Alternative Fusion Gene to EWSR1-ATF1 ', Head and neck pathology, vol. 13, no. 2, pp. 225-230 . https://doi.org/10.1007/s12105-018-0953-z Head and Neck Pathology, 13, 2, pp. 225-230 |
| ISSN: | 1936-055X |
| Popis: | Clear cell odontogenic carcinoma (CCOC) is a rare, low-grade malignant epithelial neoplasm, occurring in the jawbones, mainly affecting the mandible of elderly patients. In addition to hyalinizing clear cell carcinoma of the salivary gland, it is one of the epithelial neoplasms known to harbor an EWSR1-ATF1 fusion. Therefore, a link between these tumors seems plausible. We describe six cases of CCOC showing EWSR1 rearrangements, with two cases being positive for the ATF1 partner gene using FISH analysis. In one case, an EWSR1-CREB1 fusion was identified using RT-PCR, which we report for the first time in this tumor type. The other three cases investigated by FISH were negative for ATF1, CREB1 and CREB3L2. In conclusion, our data show that EWSR1-CREB1 is an alternative fusion gene to EWSR1-ATF1 in CCOC. |
| Databáze: | OpenAIRE |
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