The effect of glutamine on oxidative damage in an experimental abdominal compartment syndrome model in rats
| Autor: | Ridvan Seven, Deniz Tihan, Gülçin Hepgül, Yeşim Erbil, Selda Can Arkaya, Ümit Türkoğlu, Ismail Borucu |
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| Rok vydání: | 2011 |
| Předmět: |
Male
medicine.medical_specialty Antioxidant Abdominal compartment syndrome Glutamine medicine.medical_treatment Anti-Inflammatory Agents Ischemia medicine.disease_cause Compartment Syndromes Antioxidants chemistry.chemical_compound Malondialdehyde Internal medicine Pressure medicine Animals Rats Wistar Lung Peroxidase biology business.industry Glutathione medicine.disease Rats Surgery Intestines Disease Models Animal Oxidative Stress Anesthesiology and Pain Medicine Endocrinology Liver chemistry Myeloperoxidase Emergency Medicine biology.protein business Oxidative stress |
| Zdroj: | Turkish Journal of Trauma and Emergency Surgery. 17:1-8 |
| ISSN: | 1307-7945 1306-696X |
| DOI: | 10.5505/tjtes.2011.73555 |
| Popis: | Background The aim was to investigate whether or not glutamine, an antioxidant effective amino acid, improves the reperfusion-induced oxidative injury of abdominal hypertension. Methods Wistar Albino rats were used. Group 1: Abdominal compartment syndrome alone: With the rats under anesthesia, intraabdominal pressure was obtained. Three days later, the rats were sacrificed, and intestine, lung and liver samples were removed for determination of tissue malondialdehyde (MDA) and glutathione (GSH) levels as oxidative injury parameters and of myeloperoxidase (MPO) activity as an inflammatory parameter. Trunk blood was analyzed for the alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels. Group 2: Abdominal compartment syndrome and glutamine: intragastric glutamine was given for seven days before and three days following establishment of the abdominal compartment syndrome model. The same examination procedure was then performed. Group 3: Glutamine administration alone. Group 4: Control group. Results Intraabdominal pressure significantly increased the intestine, lung and liver MDA levels and MPO activities in comparison to the control group. Glutamine was associated with decreased MDA levels and MPO activities and increased GSH levels. Conclusion Glutamine appears to have protective effects against reperfusion-induced oxidative damage via its anti-inflammatory and antioxidant effect. |
| Databáze: | OpenAIRE |
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