Reactive Oxygen Species-Responsive Liposomes via Boronate-Caged Phosphatidylethanolamine
| Autor: | Jinchao Lou, Michael D. Best |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Boron Compounds
Biomedical Engineering Pharmaceutical Science Bioengineering 02 engineering and technology 01 natural sciences chemistry.chemical_compound Indolequinones Fluorescent Dyes Pharmacology chemistry.chemical_classification Phosphatidylethanolamine Reactive oxygen species Liposome 010405 organic chemistry Phosphatidylethanolamines Organic Chemistry 021001 nanoscience & nanotechnology 0104 chemical sciences chemistry Delayed-Action Preparations Liposomes Biophysics Nanocarriers Reactive Oxygen Species 0210 nano-technology Biotechnology |
| Zdroj: | Bioconjugate Chemistry. 31:2220-2230 |
| ISSN: | 1520-4812 1043-1802 |
| DOI: | 10.1021/acs.bioconjchem.0c00397 |
| Popis: | Liposomes have proven to be effective nanocarriers due to their ability to encapsulate and deliver a wide variety of therapeutic cargo. A key goal of liposome research is to enhance control over content release at diseased sites. Though a number of stimuli have been explored for triggering liposomal release, reactive oxygen species (ROS), which have received significantly less attention, provide excellent targets due to their key roles in biology and overabundance in diseased cells. Here, we report a ROS-responsive liposome platform through the inclusion of lipid |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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