Dual Porosity Expanded Polytetrafluoroethylene for Soft-Tissue Augmentation
| Autor: | Vangie B. Patula, Paul Martakos, Leigh B. Kleinert, Ted Karwoski, Stuart K. Williams, John P. Lane |
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| Rok vydání: | 2005 |
| Předmět: |
Wound Healing
medicine.medical_specialty Swine business.industry Neovascularization Physiologic Soft tissue Biocompatible Materials Biomechanical strength Penetration (firestop) Expanded polytetrafluoroethylene Plastic Surgery Procedures Biomechanical Phenomena Surgery Random Allocation Microscopy Electron Scanning Animals Swine Miniature Medicine Implant Porosity business Polytetrafluoroethylene Biomedical engineering |
| Zdroj: | Plastic and Reconstructive Surgery. 115:1995-2006 |
| ISSN: | 0032-1052 |
| DOI: | 10.1097/01.prs.0000163324.17001.e3 |
| Popis: | Background: A variety of nondegradable polymers have been evaluated for use as soft-tissue augmentation devices. This study compared a novel dual porosity expanded polytetrafluoroethylene with current, clinically used devices. Methods: Studies were performed in a porcine model of soft-tissue healing with both histologic evaluations and determination of biomechanical strength of tissue incorporation. Five different samples of expanded polytetrafluoroethylene were used in this study. Control devices were clinically available soft-tissue augmentation devices manufactured by W. L. Gore and Associates (Newark, Del.). Atrium Medical Corporation (Hudson, N.H.) manufactured three test devices with modified porosities. A total of 12 animals were used with implant evaluations performed after 1, 3, 6, and 12 months. Results: Significant differences in tissue incorporation were observed morphologically with the dual porosity material, including reduced inflammation and increased cellular and extracellular matrix incorporation of the material. Significant increases in both angiogenesis (new vessel formation in the peri-implant tissue) and neovascularization (blood vessel penetration into the interstices of the implants) were observed with the dual porosity expanded polytetrafluoroethylene material. Conclusions: This novel dual porosity expanded polytetrafluoroethylene is associated with reduced inflammation and more extensive tissue incorporation as compared with the currently available form. These results suggest a dual porosity expanded polytetrafluoroethylene may provide a superior material for soft-tissue augmentation. |
| Databáze: | OpenAIRE |
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