The insulin-like growth factor system and markers of inflammation in adult patients with inflammatory bowel disease
| Autor: | Henning Grønbæk, Allan Flyvbjerg, Jens Nederby Nielsen, Martin Eivindson, Henrik Hey |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Adult
Male Endocrinology Diabetes and Metabolism medicine.medical_treatment Inflammation Blood Sedimentation Inflammatory bowel disease Insulin-like growth factor Hemoglobins Leukocyte Count Endocrinology Crohn Disease Insulin-Like Growth Factor II Endopeptidases medicine Humans Insulin-Like Growth Factor I skin and connective tissue diseases Interleukin 6 Serum Albumin Crohn's disease biology Catabolism business.industry Interleukin-6 C-reactive protein Orosomucoid Middle Aged medicine.disease Ulcerative colitis digestive system diseases C-Reactive Protein Cross-Sectional Studies Insulin-Like Growth Factor Binding Protein 3 Pediatrics Perinatology and Child Health Immunology biology.protein Colitis Ulcerative Female sense organs medicine.symptom business |
| Zdroj: | Hormone research. 64(1) |
| ISSN: | 0301-0163 |
| Popis: | Background and Objectives:Catabolism and growth impairment are well-known complications of inflammatory bowel disease (IBD). Recent studies have demonstrated significant changes in the IGF system in IBD patients. The aim of the present study was to investigate correlations between the IGF system and markers of inflammation in IBD. Methods:A cross-sectional study comprising 99 IBD patients (Crohn’s disease (CD, n = 50) and ulcerative colitis (UC, n = 49)). Correlations between markers of inflammation and IGF-I, IGF-II and IGFBP-3 were examined in CD and UC patients in remission and relapse. The patients were clinically scored using Crohn’s Disease Activity Index (CDAI) for CD patients and Activity Index (AI) for UC patients. Results: In the UC group we found correlations between IGF-I and CRP (rs = Spearman’s rho) (rs = –0.40, p < 0.01) and albumin (rs = 0.46, p < 0.001), IGFBP-3 and albumin (rs = 0.36, p < 0.01) and AI score (rs = –0.31, p < 0.05). IGF-II correlated with CRP (rs = –0.42, p < 0.01), IL-6 (rs = –0.65, p < 0.001), albumin (rs = 0.41, p < 0.01), AI score (rs = –0.30, p < 0.05) and orosomucoid (rs = –0.47, p < 0.001). In the CD group we found correlations between IGF-I and CRP (rs = –0.40, p < 0.05), and albumin (rs = –0.46, p < 0.01), IGFBP-3 and albumin (r = 0.36, p < 0.01). IGF-II correlated with IL-6 (rs = –0.65, p < 0.001), albumin (rs = 0.41, p < 0.01), CDAI score (rs = –0.30, p < 0.05) and orosomucoid (rs = –0.47, p < 0.001). Conclusions: IGF-I, IGF-II and IGFBP-3 are correlated to albumin and IGF-I and IGF-II are correlated to CRP in IBD patients. Further, IGF-II is correlated to IL-6 in IBD patients. This may suggest a correlation between inflammation and the IGF system with involvement in muscle and bone catabolism in IBD. |
| Databáze: | OpenAIRE |
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