Are the Effects of Tamoxifen on the Serum Lipid Profile Modified by Apolipoprotein E Phenotypes?
| Autor: | Liberopoulos, E. N., Karabina, S. A., Tselepis, A., Bairaktari, Eleni Th, Nikolaides, C., Pavlidis, Nicholas, Elisaf, Moses S. |
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| Přispěvatelé: | Pavlidis, Nicholas [0000-0002-2195-9961], Elisaf, Moses S. [0000-0003-0505-078X], Liberopoulos, E. N. [0000-0002-7162-3323] |
| Rok vydání: | 2002 |
| Předmět: |
Apolipoprotein E
Cancer Research Very low-density lipoprotein Apolipoprotein B Low density lipoprotein cholesterol chemistry.chemical_compound Breast cancer Estrogen Receptor Modulators Antineoplastic agents Apolipoprotein a1 Estrogen receptor modulators Lipoprotein a Middle aged High density lipoprotein cholesterol Apolipoprotein b Priority journal Lipoprotein blood level biology medicine.diagnostic_test Apolipoprotein e4 allele density-lipoprotein cholesterol General Medicine Lipoprotein(a) Middle Aged Lipids Postmenopause hormone replacement therapy Cholesterol Phenotype Cholesterol blood level Apolipoproteins e Very low density lipoprotein Oncology Female lipids (amino acids peptides and proteins) Apolipoprotein A1 Human cardiovascular risk Adult medicine.medical_specialty Antineoplastic Agents Hormonal Hdl Clinical article Breast Neoplasms Triacylglycerol Article Blood analysis Ldl Apolipoproteins E Lipoprotein (a) Internal medicine mental disorders medicine Humans plasma Triglycerides estrogen replacement Aged Hormonal Apolipoprotein e phenotypes Cholesterol HDL Cholesterol LDL Follow up e polymorphism Body weight Gene frequency Lipid blood level Drug effect Tamoxifen Apolipoproteins Endocrinology chemistry biology.protein Breast neoplasms Prediction Lipid profile Controlled study Lipid parameters Isoelectric focusing Lipoprotein |
| Zdroj: | Oncology |
| ISSN: | 1423-0232 0030-2414 |
| Popis: | Background: Tamoxifen has favorable effects on the serum lipid profile. It has been suggested that the apolipoprotein (Apo) E phenotype can influence serum lipid parameters; the ApoE allele 4 (ApoE4) is associated with higher total and low-density lipoprotein (LDL) cholesterol levels. The ApoE phenotype also affects lipid responses to diets or treatment with statins. However, the effect of tamoxifen on the lipid profile in different ApoE phenotypes is unknown. Patients and Methods: In the present study, we evaluated the effects of tamoxifen on the serum lipid profile in 11 ApoE4-positive postmenopausal women with breast cancer (phenotypes 3/4 and 4/4) compared with 33 ApoE4-negative women (phenotypes 3/2 and 3/3). Serum lipid parameters [high-density (HDL), LDL and total cholesterol, triglycerides, ApoAI, ApoB and lipoprotein (a)] were measured after an overnight fast before treatment and after 3 and 12 months. ApoE isoforms were determined by isoelectric focusing of delipidated very-low-density lipoproteins (VLDL). Results: During the follow-up period, serum levels of total and LDL cholesterol and ApoB decreased significantly in both groups, but no significant differences were found. Concentrations of serum HDL cholesterol were not significantly different between both groups. However, serum ApoAI levels increased significantly in ApoE4-negative subjects (p = 0.00005), but no significant changes in ApoE4-positive women were observed. Serum triglyceride levels increased by 23.2% (p < 0.05) in ApoE4-positive patients, but they did not change significantly in ApoE4-negative patients. The LDL/HDL cholesterol ratio decreased similarly in the two groups, but the ApoAI/ApoB ratio, which may be a better predictor of cardiovascular events, significantly changed in the ApoE4-negative subjects. Finally, the median level of Lp(a) decreased by 43.4% in the ApoE4-negative patients, whereas it did not change significantly in the ApoE4-positive group. Conclusion: In postmenopausal Greek women with breast cancer, the levels of Lp(a) and triglycerides and the ApoAI/ApoB ratio respond more favorably to tamoxifen treatment in ApoE4-negative than in ApoE4-positive patients. |
| Databáze: | OpenAIRE |
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