Biochemical Modulation by 5-Fluorouracil and 1-Folinic Acid of Tumor Uptake of Intra-Arterial 5-[123I]Iodo-2'-Deoxyuridine in Patients with Liver Metastases from Colorectal Cancer
| Autor: | S. Ricci, Giuliano Mariani, R Bonini, D Bonora, S Buralli, Alfredo Falcone, S Di Sacco, L Di Luca, Stephen Adelstein, Janina Baranowska-Kortylewicz, Amin I. Kassis |
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| Rok vydání: | 1996 |
| Předmět: |
Male
Oncology Antimetabolites Antineoplastic medicine.medical_specialty Colorectal cancer medicine.medical_treatment Leucovorin Pharmacology Thymidylate synthase Iodine Radioisotopes chemistry.chemical_compound Folinic acid Idoxuridine Internal medicine Iodine-123 Humans Infusions Intra-Arterial Medicine Cytotoxic T cell Radiology Nuclear Medicine and imaging Aged biology business.industry Liver Neoplasms Hematology General Medicine Middle Aged medicine.disease Deoxyuridine Radiation therapy chemistry Fluorouracil biology.protein Feasibility Studies Colorectal Neoplasms business medicine.drug |
| Zdroj: | Acta Oncologica. 35:941-945 |
| ISSN: | 1651-226X 0284-186X |
| DOI: | 10.3109/02841869609104049 |
| Popis: | In previous studies we demonstrated a high tumor-targeting value of the 123I-labeled thymidine analogue 5-iodo-2'-deoxyuridine (IUdR) infused intra-arterially in patients with liver metastases from colorectal cancer. In the present study we have explored the possibility of enhancing tumor uptake of [123I]IUdR, by biochemical modulation with 5-fluorouracil (5-FU) and 1-folinic acid (FA), a drug combination known to inhibit thymidylate synthetase in tumor cells. The investigation was carried out employing diagnostic imaging doses of [123I]IUdR, much lower than possible therapeutic levels. In the baseline study, [123I]IUdR was infused into the hepatic artery of patients with inoperable liver metastases from colorectal cancer, and a second infusion was performed one week later, after intra-arterial administration of 5-FU and FA. The effect was evaluated by comparing tumor uptake of [123I]IUdR in the second study with that of the baseline study. The average tumor uptake immediately after [123I]IUdR infusion was 9.1% ID in the baseline study, increasing to 14.9% ID after pretreatment with 5-FU and FA. The average enhancement in early tumor uptake of [123I]IUdR induced by biochemical modulation was 72%. This enhancement was sustained at 18 and 42 hours after infusion (stable uptake). The results encourage the pretreatment of patients with 5-FU and FA prior to radioiodinated IUdR administration and suggest its inclusion in therapeutic protocols employing IUdR labeled with 123I or 125I as a source of highly cytotoxic Auger electrons. |
| Databáze: | OpenAIRE |
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