Anti-shock effect of pituitary adenylate cyclase activating polypeptide (PACAP) on experimental endotoxin shock in dogs
| Autor: | Kikuo Kasai, Shin-Ichi Shimoda, Yoshinobu Suzuki, Muneo Oka, Kazuhiro Takekoshi, Ichiro Iino |
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| Rok vydání: | 1994 |
| Předmět: |
Male
Cardiac function curve endocrine system Cardiac output medicine.medical_specialty Mean arterial pressure Cardiotonic Agents Epinephrine Hydrocortisone Adenylate kinase Blood Pressure Cyclase General Biochemistry Genetics and Molecular Biology Endotoxin shock Dogs Bolus (medicine) Internal medicine medicine Animals Cardiac Output General Pharmacology Toxicology and Pharmaceutics Infusions Intravenous Chemistry Neuropeptides General Medicine Shock Septic Endocrinology Injections Intravenous Pituitary Adenylate Cyclase-Activating Polypeptide Female hormones hormone substitutes and hormone antagonists Hormone |
| Zdroj: | Life Sciences. 54:PL389-PL394 |
| ISSN: | 0024-3205 |
| Popis: | Effects of pituitary adenylate cyclase activating polypeptide with 38 amino acid residues (PACAP-38) on both cardiovascular functions and plasma hormone levels during endotoxin shock were studied in anesthetized dogs. When PACAP-38 (a bolus 420 pmol/kg injection or a bolus 420 pmol/kg injection followed by a continuous 30 pmol/kg/min infusion for 60 min) was administered intravenously 5 min after application of endotoxin, both mean arterial pressure and cardiac output were restored at 10 min. The continuous administration of PACAP-38 was more effective in improving the symptoms of shock. Plasma adrenalin and cortisol levels were significantly increased by both regimens. These results clearly indicate that the anti-shock properties of PACAP-38 may be attributed to its abilities to increase plasma cortisol and adrenalin levels and to stimulate cardiac function. |
| Databáze: | OpenAIRE |
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