The measurement of regional ventilation during tidal breathing: a comparison of two methods in healthy subjects, and patients with chronic obstructive lung disease
| Autor: | Joanne Markham, J. Wilhelm, Hill Rl, R. H. Seeker-Walker, Philip O. Alderson, E. J. Potchen, J. Baker |
|---|---|
| Rok vydání: | 1975 |
| Předmět: |
Adult
Male Xenon FEV1/FVC ratio Tidal breathing Tidal Volume medicine Humans Radiology Nuclear Medicine and imaging Lung volumes Lung Diseases Obstructive Tidal volume Aged Radioisotopes Lung Computers business.industry Respiration Healthy subjects General Medicine Middle Aged respiratory system medicine.disease Obstructive lung disease respiratory tract diseases medicine.anatomical_structure Anesthesia Breathing Female Pulmonary Ventilation business |
| Zdroj: | The British Journal of Radiology. 48:181-189 |
| ISSN: | 1748-880X 0007-1285 |
| DOI: | 10.1259/0007-1285-48-567-181 |
| Popis: | Regional ventilation has been measured in 17 healthy volunteers, and 24 patients with chronic obstructive lung disease during tidal breathing using 133-Xe. The wash-in and wash-out of 133-Xe were recorded by a gamma camera interfaced to a small digital computer. Regional ventilation was calculated as the distribution of tidal volume per unit lung volume-a measure of relative ventilation--and from the wash-out curves as the fractional exchange of air per second. Determination of the regional fractional exchange of air showed a significant difference between the patients with chronic obstructive lung disease and normal subjects for all regions. The distribution of tidal volume per unit lung volume did not effect such a clear separation. Significant correlations were found between the whole-lung fractional exchange of air in the patients with chronic obstructive lung disease and their FEV1 r equal 0-70, MMFR r equal 0-70, FVC r equal 0-56 and FEV1/FVC r equal 0-57. It is suggested that measurement of regional ventilation as the fractional exchange of air is more realistic than methods that determine relative ventilation or only make use of the early part of the wash-out 133-Xe. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|