Froin Syndrome, a Rare Complication of Multiple Myeloma
Autor: | Keithan Sivakumar, Ahmad Nizam, Hussam A. Yacoub |
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Rok vydání: | 2021 |
Předmět: |
Adult
Male Pathology medicine.medical_specialty 030204 cardiovascular system & hematology 03 medical and health sciences 0302 clinical medicine Cerebrospinal fluid Xanthochromia medicine Humans Multiple myeloma medicine.diagnostic_test business.industry Magnetic resonance imaging Syndrome General Medicine medicine.disease Magnetic Resonance Imaging CSF circulation Etiology Csf analysis Nervous System Diseases Multiple Myeloma Complication business 030217 neurology & neurosurgery |
Zdroj: | The Neurologist. 26:83-85 |
ISSN: | 2331-2637 |
Popis: | Introduction Froin syndrome is a rare condition that is defined as marked coagulability, elevated protein level, and xanthochromia of the cerebrospinal fluid (CSF). Froin syndrome more commonly occurs because of obstruction of CSF flow due to underlying inflammatory or neoplastic conditions. Case report We present a case of a 38-year-old man who was found to have Froin syndrome a year after he was diagnosed with multiple myeloma (MM). CSF analysis, laboratory work-up, and magnetic resonance imaging of the neuroaxis supported the diagnosis of Froin syndrome related to leptomeningeal myelomatosis. To our knowledge, this is the first reported case of FS due to MM. Conclusion Leptomeningeal myelomatosis associated with MM can cause blockage of CSF circulation leading to Froin syndrome. Inflammatory or neoplastic conditions should be considered as an underlying etiology. |
Databáze: | OpenAIRE |
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