Evaluation of argyrophilic nucleolar organiser regions (AgNORs) in multiple myeloma
| Autor: | D Daskalopoulou, S I Papadhimitriou, S Markidou, P Tsaftaridis, M Stamatelou |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Adult
Male Silver Staining Pathology medicine.medical_specialty Myeloma protein Plasma Cells Cell Count Plasma cell Biology Pathology and Forensic Medicine chemistry.chemical_compound immune system diseases hemic and lymphatic diseases Lactate dehydrogenase Nucleolus Organizer Region medicine Humans Multiple myeloma Aged Retrospective Studies Analysis of Variance Beta-2 microglobulin C-reactive protein Albumin General Medicine Middle Aged Prognosis medicine.disease medicine.anatomical_structure chemistry Papers biology.protein Female Nucleolus organizer region Multiple Myeloma Biomarkers |
| Zdroj: | Journal of Clinical Pathology. 53:462-465 |
| ISSN: | 0021-9746 |
| Popis: | Aim—To investigate the prognostic value of argyrophylic nucleolar organiser regions (AgNORs) in multiple myeloma. Methods—Bone marrow aspirates from 55 newly diagnosed patients with multiple myeloma were stained with the one step AgNO3 technique. The mean number of AgNORs in each plasma cell nucleus (AgNOR count) was tested for a possible correlation with other clinical and laboratory variables at presentation (clinical stage, substage, heavy and light chain isotype, haemoglobin concentration, platelet count, marrow infiltration rate, degree of skeletal lesions, M protein concentration, plasma cell morphology, and serum concentrations of calcium, albumin, lactate dehydrogenase, C reactive protein, and s2 microglobulin) and with outcome (response to first line treatment, first remission duration, and overall survival). Results—A significant association between mean (SD) AgNOR count was found only for clinical stage (stage I, 3.09 (1.19); stage II, 3.80 (1.53); stage III, 5.28 (1.79); p < 0.005) and, from all stage determinants, only for M protein concentration (high, 5.92 (1.80); low, 4.01 (1.92); p < 0.001). There was a linear relation between AgNOR count and serum M protein concentration for patients with both IgG (r = 0.450; p < 0.01) and IgA (r = 0.768; p < 0.002) producing multiple myeloma. Conclusions—Unlike previous investigations, no clear prognostic value for the AgNOR count was found in multiple myeloma. Instead, the results indicate that the AgNOR count might be an index for M protein synthesis rate. This is consistent with other findings in tissues with low proliferative potential and high protein synthetic activity, and calls for a cautious interpretation of AgNORs in malignancies with similar features. Key Words: argyrophilic nucleolar organiser regions, multiple myeloma • M protein synthesis • prognosis |
| Databáze: | OpenAIRE |
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