Anti-HIV activity of new pyrazolobenzothiazine 5,5-dioxide-based acetohydrazides

Autor:	Raymond F. Schinazi, Mervi Detorio, Catherine Montero, Masood Parvez, Zunera Khalid, Sana Aslam, Matloob Ahmad, Munawar Ali Munawar
Rok vydání:	2021
Předmět:	Anti hiv activity Anti hiv 1 Chemistry Stereochemistry Organic Chemistry Pharmacology toxicology Human immunodeficiency virus (HIV) Pharmacology medicine.disease_cause Article medicine Vero cell General Pharmacology Toxicology and Pharmaceutics Cytotoxicity
Zdroj:	Med Chem Res
ISSN:	1054-2523
Popis:	A series of fifteen new 2-[3-(3-chlorophenyl)-5,5-dioxidobenzo[e]pyrazolo[4,3-c][1,2]thiazin-4(2H)-yl]-N′-arylmethyleneacetohydrazides (5a–o) were synthesized and screened for their anti-HIV-1 and cytotoxicity activity. Out of fifteen pyrazolobenzothiazine-based hydrazones, thirteen were found to be active inhibitors of HIV with EC(50) values
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c29e06f77e3456b19d1af9c75678f45 https://pubmed.ncbi.nlm.nih.gov/34316244 Zobrazit plný text záznamu Full text from SpringerLink