Synthesis and Characterization of Salicylic Acid-Based Poly(Anhydride-Ester) Copolymers
| Autor: | Kathryn E. Uhrich, Robert C. Schmeltzer |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
chemistry.chemical_classification
Polymers and Plastics Chemistry 0206 medical engineering Thermal decomposition Bioengineering 02 engineering and technology Polymer 021001 nanoscience & nanotechnology Elastomer 020601 biomedical engineering Article Biomaterials chemistry.chemical_compound Monomer Polymerization Chemical engineering Polymer chemistry Materials Chemistry Copolymer 0210 nano-technology Glass transition Salicylic acid |
| Zdroj: | Journal of bioactive and compatible polymers. 21(2) |
| ISSN: | 0883-9115 |
| Popis: | A series of poly(anhydride-esters) based on poly(1,10-bis( o-carboxyphenoxy)decanoate) (CPD) and poly(1,6-bis( p-carboxyphenoxy)hexane) ( p-CPH) were synthesized by melt-condensation polymerization. Poly-(anhydride-esters) that contain CPD hydrolytically degraded into salicylic acid, however, these homopolymers have mechanical and thermal characteristics that limit their use in clinical applications. The synthesis and characterization of copolymers of CPD with p-CPH, a monomer known to generate mechanically stable homopolymers, was investigated. By changing the CPD to p-CPH monomer ratios, the salicylic acid loading and thermal/mechanical properties of the copolymers was a controlling factor; increasing the CPD concentration increased the salicylate loading but decreased the polymer stability; whereas increasing the p-CPH concentration increased the thermal and mechanical stability of the copolymers. Specifically, decreasing the CPD: p-CPH ratio resulted in lower salicylate loading and increased thermal decomposition temperatures. The glass transition temperatures (°C) varied from 27 to 38°C, a desirable range for elastomeric biomedical implants. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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