Miktoarm Amphiphilic Block Copolymer with Singlet Oxygen-Labile Stereospecific β-Aminoacrylate Junction: Synthesis, Self-Assembly, and Photodynamically Triggered Drug Release
| Autor: | Dae Heon Kim, Gurusamy Saravanakumar, Jinhwan Kim, Hyeongmok Park, Won Jong Kim, Swapan Pramanick, Dongsik Park |
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| Rok vydání: | 2018 |
| Předmět: |
Porphyrins
Polymers and Plastics Polyesters Breast Neoplasms Bioengineering 02 engineering and technology Polyethylene glycol 010402 general chemistry 01 natural sciences Ring-opening polymerization Polyethylene Glycols Biomaterials chemistry.chemical_compound Polymethacrylic Acids Cell Line Tumor Polymer chemistry Amphiphile Materials Chemistry Copolymer Humans Chlorophyllides Singlet Oxygen Singlet oxygen technology industry and agriculture 021001 nanoscience & nanotechnology 0104 chemical sciences Photochemotherapy chemistry Doxorubicin Delayed-Action Preparations Polycaprolactone Click chemistry Click Chemistry Female Self-assembly 0210 nano-technology |
| Zdroj: | Biomacromolecules. 19:2202-2213 |
| ISSN: | 1526-4602 1525-7797 |
| DOI: | 10.1021/acs.biomac.8b00290 |
| Popis: | Incorporation of a desired stimuli-responsive unit in a stereospecific manner at the specific location within a nonlinear block copolymer architecture is a challenging task in synthetic polymer chemistry. Herein, we report a facile and versatile method to synthesize AB2 miktoarm block copolymers bearing a singlet oxygen (1O2)-labile regio and stereospecific β-aminoacrylate linkage with 100% E-configuration at the junction via a combination of amino-yne click chemistry and ring opening polymerization. Using this strategy, a series of 1O2-responsive AB2 amphiphilic miktoarm (MA) copolymers composed of hydrophilic polyethylene glycol (PEG) as the A constituent and hydrophobic polycaprolactone (PCL) as the B constituent (MA-PEG-b-PCL2) was synthesized by varying the block length of PCL. The self-assembly characteristics of these well-defined MA-PEG-b-PCL2 copolymers in an aqueous condition were studied by solvent displacement and thin-film hydration method, and their morphologies were investigated using trans... |
| Databáze: | OpenAIRE |
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