Impaired aldosterone secretion from dispersed adrenal capsular cells of chronically alpha-MSH-treated rats
| Autor: | Arunabha Ganguly, David Sumpter, Tracy Hampton, Shirley Chiou |
|---|---|
| Rok vydání: | 1986 |
| Předmět: |
Male
medicine.medical_specialty medicine.medical_treatment Clinical Biochemistry 8-Bromo Cyclic Adenosine Monophosphate Biology Biochemistry Potassium Chloride chemistry.chemical_compound Basal (phylogenetics) Endocrinology Adrenocorticotropic Hormone Internal medicine medicine Animals Secretion Melanocyte-Stimulating Hormones Molecular Biology Saline Aldosterone Pharmacology Adrenal cortex Organic Chemistry Rats Inbred Strains Rats Steroid hormone medicine.anatomical_structure chemistry Adrenal Cortex hormones hormone substitutes and hormone antagonists Intracellular Hormone |
| Zdroj: | Steroids. 47(4-5) |
| ISSN: | 0039-128X |
| Popis: | To investigate the chronic effects of alpha-melanocyte-stimulating hormone (alpha-MSH) on aldosterone secretion, synthetic alpha-MSH (8 micrograms/day) was infused in Sprague-Dawley rats by miniosmotic pumps for 5 days. Saline was infused in equivalent volume for 5 days using the same type of pumps in the control group of rats. Aldosterone secretion from the capsular cells of the two groups was examined in the basal state and in response to various stimuli of aldosterone secretion. Aldosterone secretion in vitro from the alpha-MSH-treated rats was significantly impaired in response to all stimuli tested including cyclic AMP, suggesting an intracellular defect in aldosterone synthesis in that group. These results are similar to those observed after chronic adrenocorticotropin administration. |
| Databáze: | OpenAIRE |
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