Rifampicin-associated acute renal failure and hemolysis: a rather uncommon but severe complication

Autor:	Styliani Papaemmanouil, Konstaninos Zarogoulidis, Karmen Tasiopoulou, Katerina Manika, Ioannis Kioumis, Leuteris Vlogiaris, Martha Lada
Rok vydání:	2013
Předmět:	Male medicine.medical_specialty Tuberculosis medicine.drug_class Antibiotics Critical Care and Intensive Care Medicine Hemolysis Biopsy medicine Humans Acute tubulointerstitial nephritis Antibiotics Antitubercular Tuberculosis Pulmonary Kidney medicine.diagnostic_test business.industry Furosemide General Medicine Acute Kidney Injury Middle Aged medicine.disease Surgery medicine.anatomical_structure Nephrology Rifampin business Rifampicin medicine.drug
Zdroj:	Renal failure. 35(8)
ISSN:	1525-6049
Popis:	Rifampicin is a widely used anti-tuberculosis agent. Apart from hepatotoxicity, rifampicin can rarely lead to adverse reactions of immunologic nature such as acute renal failure (ARF). We report the case of 57-year-old previously healthy man under treatment for pulmonary tuberculosis who presented with hemolysis and severe ARF. Rifampicin was discontinued and the patient was treated with fluid repletion, iv furosemide and dialysis therapy. Kidney biopsy revealed acute tubulointerstitial nephritis with no evidence of granulomas. The patient significantly improved and was discharged after 51 days of hospitalization. Clinicians using rifampicin should be aware of this rather uncommon but severe complication.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c2558bedd4c3686cd79cb8977e19f97 https://pubmed.ncbi.nlm.nih.gov/23883374 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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