Impact of gender on the decision to participate in a clinical trial: a cross-sectional study
| Autor: | David Diemert, Jeffrey M. Bethony, Fernanda Bicalho Pereira, Maria Flávia Gazzinelli, Lucas Lobato, Shannon Grahek |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Male Cross-sectional study media_common.quotation_subject Decision Making Clinical research Social influence Sex Factors Informed consent Surveys and Questionnaires Medicine Humans Patient participation Voluntariness Autonomy media_common Clinical Trials as Topic Informed Consent business.industry Public Health Environmental and Occupational Health Gender Middle Aged Bioethics Healthy Volunteers Clinical trial Cross-Sectional Studies Socioeconomic Factors Female Biostatistics Patient Participation business Brazil Clinical psychology Research Article |
| Zdroj: | BMC Public Health |
| ISSN: | 1471-2458 |
| Popis: | Background In order for Informed Consent to be ethical and valid each clinical trial participant must be able to make a voluntary decision to participate, free from pressure or coercion. Nonetheless, many factors may influence the decision reached, and such influences may be different for male and female volunteers. Being aware of these differences may help researches develop better processes for obtaining consent that safeguard the right of autonomy for all participants. The goal of this study was to evaluate potential gender-based differences in the factors influencing clinical trial participation. Methods This cross-sectional study was conducted in the Northeast region of Minas Gerais, Brazil, in October 2011. A structured questionnaire was administered to 143 volunteers (48 male, 95 female) screened for participation in a clinical study of an investigational functional food with potential anthelminthic properties. Answers regarding their decision to participate in the study were compared, by gender, using chi-square and Mann Whitney tests. Odds ratios (OR) was used to measure association. Results A majority of subjects (58% of males, 59% of females) listed the desire to collaborate with the development of a product against parasitic worms as their main reason for participation. Females were significantly more likely to report a decision influenced by friends, family, or researchers (OR 3.14, 3.45, and 3.46 respectively, p |
| Databáze: | OpenAIRE |
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