Associations of atrophic gastritis and proton-pump inhibitor drug use with vitamin B-12 status, and the impact of fortified foods, in older adults
| Autor: | M. Clements, Anne M. Molloy, Mary Ward, Miriam Casey, Liadhan McAnena, Eamon Laird, Catherine F Hughes, Fergal Tracey, Leane Hoey, Helene McNulty, James J. Strain, Conal Cunningham, Kevin McCarroll, Maurice O'Kane, K. Porter, Kristina Pentieva |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Gastritis
Atrophic Male Drug Vitamin Aging medicine.medical_specialty Atrophic gastritis medicine.drug_class media_common.quotation_subject Nutritional Status Medicine (miscellaneous) Proton-pump inhibitor proton pump inhibitor drugs Gastroenterology AcademicSubjects/MED00160 AcademicSubjects/MED00060 chemistry.chemical_compound food-bound malabsorption atrophic gastritis Internal medicine Prevalence medicine Humans Vitamin B12 Fortified Food older adults Aged fortified foods media_common Nutrition and Dietetics Pepsinogens business.industry Achlorhydria hypochlorhydria Proton Pump Inhibitors Vitamin B 12 Deficiency medicine.disease Vitamin B 12 Original Research Communications chemistry Food Fortified Vitamin B Complex Cohort vitamin B-12 biomarkers Gastric acid Female business Biomarkers |
| Zdroj: | The American Journal of Clinical Nutrition |
| ISSN: | 0002-9165 |
| Popis: | Background Atrophic gastritis (AG) and use of proton pump inhibitors (PPIs) result in gastric acid suppression that can impair the absorption of vitamin B-12 from foods. The crystalline vitamin B-12 form, found in fortified foods, does not require gastric acid for its absorption and could thus be beneficial for older adults with hypochlorhydria, but evidence is lacking. Objectives To investigate associations of AG and PPI use with vitamin B-12 status, and the potential protective role of fortified foods, in older adults. Methods Eligible participants (n = 3299) not using vitamin B-12 supplements were drawn from the Trinity-Ulster and Department of Agriculture cohort, a study of noninstitutionalized adults aged ≥60 y and recruited in 2008–2012. Vitamin B-12 status was measured using 4 biomarkers, and vitamin B-12 deficiency was defined as a combined indicator value |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|