Chemical Demethylation of Methylmercury by Selenoamino Acids
| Autor: | Mohammad A. K. Khan, Feiyue Wang |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Glutathione metabolism
Magnetic Resonance Spectroscopy Dimethylmercury General Medicine Nuclear magnetic resonance spectroscopy Methylmercury Compounds Toxicology Glutathione Selenocysteine chemistry.chemical_compound Selenocysteine metabolism chemistry Organoselenium Compounds Selenide Organic chemistry Selenomethionine Methylmercury Demethylation |
| Zdroj: | Chemical Research in Toxicology. 23:1202-1206 |
| ISSN: | 1520-5010 0893-228X |
| DOI: | 10.1021/tx100080s |
| Popis: | A new chemical demethylation pathway for methylmercury under physiologically and environmentally relevant conditions is reported. The pathway involves the reaction between methylmercury and a selenoamino acid (L-selenocysteine, L-selenoglutathione, D,L-selenopenicillamine, or L-selenomethionine) via the formation of bis(methylmercuric)selenide and dimethylmercury as intermediates. The final degradation product is HgSe(s). |
| Databáze: | OpenAIRE |
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