Association ofIL1RNVNTR polymorphism with chikungunya infection: A study from Western India
| Autor: | Subrat Thanapati, Lata Sonam, Shaila Puranik, Anuradha S. Tripathy, Mohini A. Ganu, Pooja Gupta, Kalichamy Alagarasu, Atul M. Walimbe |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male Adolescent Genotype viruses India Minisatellite Repeats medicine.disease_cause Virus law.invention Young Adult 03 medical and health sciences 0302 clinical medicine Polymorphism (computer science) law Virology parasitic diseases Genetic model medicine Humans Genetic Predisposition to Disease 030212 general & internal medicine Chikungunya Allele Child Alleles Genetic Association Studies Polymerase chain reaction Aged Polymorphism Genetic business.industry virus diseases Middle Aged Interleukin 1 Receptor Antagonist Protein Infectious Diseases Interleukin 1 receptor antagonist Child Preschool Chronic Disease Chikungunya Fever Cytokines Female 030211 gastroenterology & hepatology business |
| Zdroj: | Journal of Medical Virology. 91:1901-1908 |
| ISSN: | 1096-9071 0146-6615 |
| Popis: | Chikungunya, caused by the chikungunya virus (CHIKV) mostly presents as acute and chronic articular inflammatory manifestations. Interleukin 1 receptor antagonist (IL-1RN) is a potent endogenous competitive inhibitor of IL-1α and 1β and has an anti-inflammatory role. The present study evaluated the possible association of IL1RN variable number tandem-repeat (VNTR) alleles and genotypes, and CHIKV stimulated IL-1RN cytokine production with resistance and/or susceptibility to chikungunya infection and disease state in 224 patients with chikungunya (61 patients with acute chikungunya and 163 patients with chronic chikungunya) and 355 healthy controls. Polymerase chain reaction, CHIKV stimulated cytokine assay and luminex platform were used for assessing polymorphism and protein levels respectively. The study revealed a significant association of IL1RN*1/*1 genotype under recessive genetic model with the risk of developing chikungunya infection. Our findings also indicated that IL1RN *2 allele under dominant mode was associated with protection to chronic chikungunya. The results also revealed a higher production of IL-1 RN protein in patients with chronic chikungunya. To conclude, the results suggest the association of ILRN VNTR polymorphism and IL-RN protein levels with chronic chikungunya. |
| Databáze: | OpenAIRE |
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