Inconsistency in the reporting of antitubercular drug susceptibility tests in an endemic region
| Autor: | Kamlesh V Pandey, Preyas J Vaidya, Avinandan Saha, Prashant N Chhajed, Arvind H Kate, Vinod B Chavhan |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
lcsh:RC705-779
Pulmonary and Respiratory Medicine medicine.medical_specialty Tuberculosis drug susceptibility testing business.industry Individualized treatment lcsh:Diseases of the respiratory system Drug susceptibility Drug resistance medicine.disease Ciprofloxacin tuberculosis Internal medicine medicine Original Article business medicine.drug |
| Zdroj: | Lung India : Official Organ of Indian Chest Society Lung India, Vol 34, Iss 5, Pp 427-429 (2017) |
| ISSN: | 0970-2113 |
| Popis: | Background: Individualized treatment for multidrug-resistant tuberculosis (MDR TB) is associated with improved outcomes. Therapy needs to be tailored to drug susceptibility testing (DST) results. We present our observations on the inconsistency in DST reporting in an endemic region with a high prevalence of MDR TB. Methods: We retrospectively analyzed 118 DST reports from 10 different laboratories. Observations: Of 118 patients, only 79 (67%) had DST reports with results to all first-line drugs, a fluoroquinolone (excluding ciprofloxacin), all aminoglycosides, and a polypeptide. Twenty-one (18%) isolates did not have DST reports for all first-line drugs; 4 (3%) did not have DST reports for any second-line drugs; 9 (8%) did not have DST reports for a fluoroquinolone; and 31 (26%) did not have DST reports for all second-line aminoglycosides and polypeptide. Conclusion: Inconsistencies were observed in several of the 118 DST reports. A case is made for sensitization toward standardization and completeness in TB DST reporting in India. |
| Databáze: | OpenAIRE |
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