Cefiderocol (S-649266), A new siderophore cephalosporin exhibiting potent activities against Pseudomonas aeruginosa and other gram-negative pathogens including multi-drug resistant bacteria: Structure activity relationship

Autor:	Jun Sato, Yasushi Hasegawa, Kenji Yamawaki, Takafumi Sato, Masayuki Sano, Shinya Hisakawa, Masakatsu Tsuji, Yasuhiro Nishitani, Toshiaki Aoki, Toru Nishikawa, Hiroki Kusano, Rio Nakamura, Hidenori Yoshizawa, Katsuki Yokoo, Yoshinori Yamano, Hideki Sugimoto
Rok vydání:	2018
Předmět:	0301 basic medicine Siderophore medicine.drug_class Multi drug resistant bacteria 030106 microbiology Cephalosporin Microbial Sensitivity Tests medicine.disease_cause 01 natural sciences Microbiology 03 medical and health sciences Structure-Activity Relationship Drug Discovery Gram-Negative Bacteria polycyclic compounds medicine Structure–activity relationship Pharmacology biology Dose-Response Relationship Drug Molecular Structure 010405 organic chemistry Pseudomonas aeruginosa Chemistry Organic Chemistry General Medicine biochemical phenomena metabolism and nutrition bacterial infections and mycoses biology.organism_classification Enterobacteriaceae 0104 chemical sciences Acinetobacter baumannii Anti-Bacterial Agents Cephalosporins Stenotrophomonas maltophilia
Zdroj:	European journal of medicinal chemistry. 155
ISSN:	1768-3254
Popis:	The structure-activity relationship (SAR) for a novel series of catechol conjugated siderophore cephalosporins is described with their in vitro activities against multi-drug resistant Gram-negative pathogens including Pseudomonas aeruginosa, Acinetobacter baumannii, Stenotrophomonas maltophilia and Enterobacteriaceae. Cefiderocol (3) was one of the best molecules which displayed well-balanced and potent activities against multi-drug resistant Gram-negative pathogens including carbapenem resistant bacteria among the prepared compounds with the modified C-7 side chain and the modified C-3 side chain. Cefiderocol (3) is a highly promising parenteral cephalosporin for the treatment of multi-drug resistant Gram-negative infection.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c1fb65f3d6afacc1db14fba6f5f13f1 https://pubmed.ncbi.nlm.nih.gov/29960205 Zobrazit plný text záznamu Full Text from ScienceDirect